Mammalian pro-alpha3(V) collagen chain genes
AssigneeWisconsin Alumni Research Foundation
InventorsDaniel S. Greenspan, Yasutada Imamura
Life of this patent
Estimating the term…
Abstract
Mammalian α3(V) pro-collagen and collagen polypeptides and variants thereof are encoded by exemplified polynucleotides. Investigative, diagnostic and therapeutic methods employ the polypeptides, polynucleotides and related materials, such as antibodies, sense- or antisense oligonucleotides and polynucleotides, and the like.
Claims23
An isolated polynucleotide selected from the group consisting of a polynucleotide that encodes a polypeptide selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 4, and a polypeptide having at least 80% identity with either of the foregoing, a polynucleotide having at least 80% identity with any of the foregoing, a polynucleotide that hybridizes under stringent hybridization conditions with any of the foregoing, and a complement of any of the foregoing.
An isolated polynucleotide selected from the group consisting of SEQ ID NO:
- 1 between bases 82 and 5298 and a complement of any of the foregoing.
An isolated polynucleotide selected from the group consisting of SEQ ID NO:
- 3 between bases 87 and 5321 and a complement of any of the foregoing.
An expression vector, comprising:
- a polypeptide-encoding polynucleotide selected from the group consisting of a polynucleotide that encodes a polypeptide selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 4, and a polypeptide having at least 80% identity with either of the foregoing, a polynucleotide having at least 80% identity with any of the foregoing, a polynucleotide that hybridizes under stringent hybridization conditions with any of the foregoing, and a complement of any of the foregoing;
- and
- a transcriptional control element operably linked to the polypeptide-encoding polynucleotide.
An isolated polypeptide selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 2 between amino acids 30 and 1739, and SEQ ID NO:
- 4 between amino acids 30 and 1745, and a polypeptide having at least 80% identity to any of the foregoing.
Dependencies are inferred from the claim text.