Sublancin lantibiotic produced by Bacillus subtilis 168
AssigneeUniversity of Maryland
InventorJ. Norman Hansen
Life of this patent
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Abstract
An antimicrobial peptide produced by Bacillus subtilis 168 was isolated and characterized and named sublancin 168. The invention includes DNA encoding for the sublancin 168 peptides and peptides which are at least 80% identical to the sublancin 168 peptide. The peptides may be administered as anti-bacterials, or may be used in food preservation. The peptides may also be co-administered with other lantibiotics (such as nisin and subtilin), or with known antibiotics.
Claims29
A peptide having an amino acid sequence which is at least 80% identical with SEQ ID NO:
- 7 prior to dehydration of serines and threonines and formation of thioether cross-linkages.
A peptide having an amino acid sequence which is at least 80% identical with SEQ ID NO:
- 5 prior to dehydration of serines and threonines and formation of thioether cross-linkages.
A peptide having an amino acid sequence which is at least 80% identical with SEQ ID NO:
- 18.
A DNA having a nucleic acid sequence which is at least 80% identical with nucleotides 219-389 of SEQ ID NO:
- 4.
A DNA having a nucleic acid sequence which is at least 80% identical with nucleotides 447-782 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.