Melanin concentrating hormone receptors
AssigneeNeurogen Corporation
InventorsMichele Bennett Kinrade, Robbin Brodbeck, James Krause
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Abstract
Isolated polynucleotides encoding monkey Melanin Concentrating Hormone (MCH) Type 1 receptors and chimeric polypeptides are provided. Vectors and cells for recombinant expression of such MCH1R polypeptides, and isolated MCH1R polypeptides are also provided. MCH1R polynucleotides and polypeptides may be used, for example, to identify compounds that specifically interact with MCH receptor. Such compounds find use within therapies for humans and animals afflicted with conditions associated with MCH receptor activation.
Claims32
An isolated polypeptide comprising at least 30 consecutive amino acids present within amino acids 1 to 130 of a cynomolgus macaque MCH1R sequence recited in SEQ ID NO:56, wherein the polypeptide exhibits MCH1R ligand binding activity.
An MCH1R chimeric polypeptide, comprising a MCH1R sequence in which the third intracellular loop, N-terminal and/or C-terminal domain is replaced with a corresponding domain of MCH2R, NPY1 receptor or beta-2-adrenergic receptor, and wherein the polypeptide exhibits MCH1R ligand binding activity.
Dependencies are inferred from the claim text.