Bioerodible conducting materials
AssigneeMassachusetts Institute of Technology
InventorsVenkatram Prasad Shastri, Alexander Zelikin, David Lynn, Robert S. Langer, Ivan Martin
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Abstract
The present invention specifically contemplates a polymer, preferably an electrically conductive polymer, derived from substituted pyrrolyl moieties.
Claims19
A polymer composition comprising a plurality of subunits having a structure of Formula I:
- Error! Objects cannot be created from editing field codes. Formula I
- wherein, as valence and stability permit, and independently for each subunit,
- X represents O or S;
- R1 is absent or represents a substituent on the ring to which it is attached;
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl, preferably H or lower alkyl;
- and
- m represents an integer from 0 to 10, preferably from 1 to 6.
A polymer represented by Formula II:
- 11
- wherein, as valence and stability permit,
- X represents O or S;
- R1 is absent or represents a substituent on the ring to which it is attached;
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, aralkyl, or heteroaralkyl;
- m represents an integer from 0 to 10, preferably from 1 to 6;
- and
- n represents an integer greater than 5
A polymer comprising a plurality of subunits having a structure of Formula III:
- 12
- wherein, as valence and stability permit, and independently for each subunit,
- X represents O or S;
- Z represents a substituent that is charged under physiological conditions or is hydrolyzable to such a substituent under physiological conditions;
- L represents a substituted or unsubstituted alkyl moiety;
- R1 is absent or represents a substituent on the ring to which it is attached;
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl;
- and
- m represents an integer from 0 to 10.
A polymer comprising a region having a structure of the formula:
- 13
- wherein, as valence and stability permit,
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, aralkyl, or heteroaralkyl, preferably H or lower alkyl;
- m represents an integer from 0 to 10;
- and
- n represents an integer greater than 5.
A method for preparing a polymer comprising polymerizing one or more monomers having a structure of Formula V:
- 14
- wherein, as valence and stability permit,
- X represents O or S;
- X1 and X2 independently represent H, halogen, trialkylstannyl, or a boronic acid or boronic ester moiety;
- Z represents a substituent that is charged under physiological conditions or is hydrolyzable to such a substituent under physiological conditions, such as C(═O)XR, P(═O)(OR)2, SO3R, +NR3, NR2, or a guanidine or guanidinium substituent;
- L represents a substituted or unsubstituted alkyl moiety;
- R1 is absent or represents a substituent on the ring to which it is attached;
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl;
- and
- m represents an integer from 0 to 10.
A method for preparing a polymer comprising polymerizing one or more monomers having a structure of Formula VI:
- 15
- wherein, as valence and stability permit,
- X represents O or S;
- X1 and X2 independently represent H, halogen, trialkylstannyl, or a boronic acid or boronic ester moiety;
- R1 is absent or represents a substituent on the ring to which it is attached;
- R represents H or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl;
- and
- m represents an integer from 0 to 10.
Dependencies are inferred from the claim text.