Method of treating hair loss using diphenylether derivatives

A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by the structure:

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• and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein:
• R is selected from the group consisting of hydrogen, hydroxy, esterified hydroxy, and etherified hydroxy;
• R1, R2, and R4 are each, independently, selected from the group consisting of hydrogen, halogen, trifluoromethyl and lower alkyl;
• R3 is selected from the group consisting of halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, and:
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• R8 is selected from the group consisting of hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl, and cycloalkyl-lower alkyl;
• R9 is selected from the group consisting of hydroxy and acyloxy;
• R10 is selected from the group consisting of hydrogen and lower alkyl;
• with the proviso that R9 and R10 collectively optionally represent oxo;
• W is selected from the group consisting of —O— and —S—;
• X is selected from the group consisting of —NR7, S, and O;
• R5 is selected from the group consisting of hydrogen, lower alkyl, and aryl-lower alkyl and R6 is hydrogen;
• with the proviso that when X is —NR7, R5 and R6 together are optionally oxo;
• R7 is selected from the group consisting of hydrogen and lower alkyl;
• and
• Z is selected from the group consisting of carboxyl and carboxyl derivatized as a pharmaceutically acceptable ester or amide.