Amide derivatives for the treatment of diseases mediated by cytokines

The use of a compound of the Formula I

• 12
• wherein:
• R1 and R2 which may be the same or different are selected from hydroxy C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino, di-(C1-6alkyl)amino, carboxy, C1-6alkoxycarbonyl, carbamoyl, C1-6alkylcarbamoyl, di-C1-6alkylcarbamoyl, C1-6alkylsulphonyl, arylsulphonyl, C1-6alkylaminosulphonyl, di-(C1-6alkyl)aminosulphonyl, nitro, cyano, cyanoC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-6alkanoylamino, C1-6alkoxycarbonylamino, C1-6alkanoyl, C1-6alkanoyloxy, C1-6alkyl, halo, trifluoromethyl, aryl, arylC1-6alkyl, arylC1-6alkoxy, heteroaryl, heteroarylC1-6alkyl, heterocyclyl and heterocyclylC1-6alkyl;
• m and p, are independently 0-3, and when m and/or p is 2 or 3 each R group may be the same or different;
• R3 is C1-4alkyl;
• q is 0-4;
• R4 is aryl or cycloalkyl wherein R4 is optionally substituted with up to 3 substituents having any value defined for R1;
• or a pharmaceutically-acceptable salt or in vivo cleavable ester thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines.