Hydroxy alkyl amines

A compound of the formula:

• 365
• or a pharmaceutically acceptable salt thereof, wherein RN is:
• 366
• wherein
• R4 is selected from the group consisting of H;
• NH2;
• —NH—(CH2)n6—R4-1;
• —NHR8;
• —NR50C(O)R5;
• C1-C4 alkyl-NHC(O)R5;
• —(CH2)0-4R8;
• —O—C1-C4 alkanoyl;
• OH;
• C6-C10 aryloxy optionally substituted with 1, 2, or 3 groups that are independently halogen, C1-C4 alkyl, —CO2H, —C(O)—C1-C4 alkoxy, or C1-C4 alkoxy;
• C1-C6 alkoxy;
• aryl C1-C4 alkoxy;
• —NR50CO2R51;
• —C1-C4 alkyl-NR50CO2R51;
• —C≡N;
• —CF3;
• —CF2—CF3;
• —C≡CH;
• —CH2—CH═CH2;
• —(CH2)1-4—R4-1;—(CH2)1-4—NH—R4-1;
• —O—(CH2)n6—R4-1;
• —S—(CH2)n6—R4-1;
• —(CH2)0-4—NHC(O)—(CH2)0-6—R52;
• —(CH2)0-4—R53—(CH2)0-4—R54;
• wherein
• n6 is 0, 1, 2, or 3;
• n7 is 0, 1, 2, or 3;
• R4-1 is selected from the group consisting of —SO2—(C1-C8 alkyl), —SO—(C1-C8 alkyl), —S—(C1-C8 alkyl), —S—CO—(C1-C6 alkyl), —SO2—NR4-2R4-3;
• —CO—C1-C2 alkyl;
• —CO—NR4-3R4-4;
• R4-2 and R4-3 are independently H, C1-C3 alkyl, or C3-C6 cycloalkyl;
• R4-4 is alkyl, arylalkyl, alkanoyl, or arylalkanoyl;
• R4-6 is—H or C1-C6 alkyl;
• R5 is selected from the group consisting of C3-C7 cycloalkyl;
• C1-C6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, —NR6R7, C1-C4 alkoxy, C5-C6 heterocycloalkyl, C5-C6 heteroaryl, C6-C10 aryl, C3-C7 cycloalkyl C1-C4 alkyl, —S—C1-C4 alkyl, —SO2—C1-C4 alkyl, —CO2H, —CONR6R7, —CO2—C1-C4 alkyl, C6-C10 aryloxy;
• heteroaryl optionally substituted with 1, 2, or 3 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, halogen, C1-C4 haloalkyl, or OH;
• heterocycloalkyl optionally substituted with 1, 2, or 3 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, halogen, or C2-C4 alkanoyl;
• aryl optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, OH, C1-C4 alkyl, C1-C4 alkoxy, or C1-C4 haloalkyl;
• and —NR6R7;
• wherein
• R6 and R7 are independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkanoyl, phenyl, —SO2—C1-C4 alkyl, phenyl C1-C4 alkyl;
• R8 is selected from the group consisting of —SO2—heteroaryl, —SO2-aryl, —SO2-heterocycloalkyl, —SO2—C1-C10 alkyl, —C(O)NHR9, heterocycloalkyl, —S—C1-C6 alkyl, —S—C2-C4 alkanoyl, wherein R9 is aryl C1-C4 alkyl, C1-C6 alkyl, or H;
• R50 is H or C1-C6 alkyl;
• R51 is selected from the group consisting of aryl C1-C4 alkyl;
• C1-C6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, cyano, heteroaryl, —NR6R7, —C(O)NR6R7, C3-C7 cycloalkyl, or —C1-C4 alkoxy;
• heterocycloalkyl optionally substituted with 1 or 2 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, halogen, C2-C4 alkanoyl, aryl C1-C4 alkyl, and —SO2 C1-C4 alkyl;
• alkenyl;
• alkynyl;
• heteroaryl optionally substituted with 1, 2, or 3 groups that are independently OH, C1-C4 alkyl, C1-C4 alkoxy, halogen, NH2, NH(C1-C6 alkyl) or N(C1-C6 alkyl)(C1-C6 alkyl);
• heteroarylalkyl optionally substituted with 1, 2, or 3 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, halogen, NH2, NH(C1-C6 alkyl) or N(C1-C6 alkyl)(C1-C6 alkyl);
• aryl;
• heterocycloalkyl;
• C3-C8 cycloalkyl;
• and cycloalkylalkyl;
• wherein the aryl;
• heterocycloalkyl, C3-C8 cycloalkyl, and cycloalkylalkyl groups are optionally substituted with 1, 2, 3, 4 or 5 groups that are independently halogen, CN, NO2, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, hydroxy, C1-C6 hydroxyalkyl, C1-C6 alkoxy C1-C6 alkyl, C1-C6 thioalkoxy, C1-C6 thioalkoxy C1-C6 alkyl, or C1-C6 alkoxy C1-C6 alkoxy;
• R52 is heterocycloalkyl, heteroaryl, aryl, cycloalkyl, —S(O)0-2—C1-C6 alkyl, CO2H, —C(O)NH2, —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —CO2-alkyl, —NHS(O)0-2—C1-C6 alkyl, —N(alkyl)S(O)0-2—C1-C6 alkyl, —S(O)0-2-heteroaryl, —S(O)0-2-aryl, —NH(arylalkyl), —N(alkyl)(arylalkyl), thioalkoxy, or alkoxy, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkyl, alkoxy, thioalkoxy, halogen, haloalkyl, haloalkoxy, alkanoyl, NO2, CN, alkoxycarbonyl, or aminocarbonyl;
• R53 is absent, —O—, —C(O)—, —NH—, —N(alkyl)-, —NH—S(O)0-2—, —N(alkyl)-S(O)0-2—, —S(O)0-2—NH—, —S(O)0-2-N(alkyl)-, —NH—C(S)—, or —N(alkyl)-C(S)—;
• R54 is heteroaryl, aryl, arylalkyl, heterocycloalkyl, CO2H, —CO2-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —C(O)NH2, C1-C8 alkyl, OH, aryloxy, alkoxy, arylalkoxy, NH2, NH(alkyl), N(alkyl)(alkyl), or —C1-C6 alkyl-CO2—C1—C6 alkyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkyl, alkoxy, CO2H, —CO2-alkyl, thioalkoxy, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, alkanoyl, NO2, CN, alkoxycarbonyl, or aminocarbonyl;
• X is selected from the group consisting of —C1-C6 alkylidenyl optionally optionally substituted with 1, 2, or 3 methyl groups;
• and —NR4-6—;
• or
• R4 and R4-6 combine to form —(CH2)n10—, wherein n10 is 1, 2, 3, or 4;
• Z is selected from the group consisting of a bond;
• SO2;
• SO;
• S;
• and C(O);
• Y is selected from the group consisting of H;
• C1-C4 haloalkyl;
• C5-C6 heterocycloalkyl;
• C6-C10 aryl;
• OH;
• —N(Y1)(Y2);
• C1-C10 alkyl optionally substituted with 1 thru 3 substituents which can be the same or different and are selected from the group consisting of halogen, hydroxy, alkoxy, thioalkoxy, and haloalkoxy;
• C3-C8 cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from C1-C3 alkyl, and halogen;
• alkoxy;
• aryl optionally substituted with halogen, alkyl, alkoxy, CN or NO2;
• arylalkyl optionally substituted with halogen, alkyl, alkoxy, CN or NO2;
• wherein
• Y1 and Y2 are the same or different and are H;
• C1-C10 alkyl optionally substituted with 1, 2, or 3 substituents selected from the group consisting of halogen, C1-C4 alkoxy, C3-C8 cycloalkyl, and OH;
• C2-C6 alkenyl;
• C2-C6 alkanoyl;
• phenyl;
• —SO2—C1-C4 alkyl;
• phenyl C1-C4 alkyl;
• or C3-C8 cycloalkyl C1-C4 alkyl;
• or
• Y1, Y2 and the nitrogen to which they are attached form a ring selected from the group consisting of piperazinyl, piperidinyl, morpholinyl, and pyrolidinyl, wherein each ring is optionally substituted with 1, 2, 3, or 4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, or halogen;
• R20 at each occurrence is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, hydroxy C1-C6 alkyl, halo C1-C6 alkyl, C1-C6 alkanoyl, each of which is unsubstituted or substituted with 1, 2, 3, or 4 groups independently selected from halogen, alkyl, hydroxy, alkoxy, and NH2, and —R26-R27, wherein
• R26 is selected from the group consisting of —C(O)—, —SO2—, —CO2—, —C(O)NH—, and —C(O)N(C1-C6 alkyl)-;
• R27 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, aryl C1-C6 alkyl, heterocycloalkyl, and heteroaryl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, halogen, haloalkyl, hydroxyalkyl, —C(O)NH2, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)(C1-C6 alkyl), —C(O)NH(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R1 is —(CH2)1-2—S(O)0-2—(C1-C6 alkyl), or
• C1-C10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, ═O, —SH, —C≡N, —CF3, —C1-C3 alkoxy, amino, mono- or dialkylamino, —N(R)C(O)R′—, —OC(═O)-amino and —OC(═O)-mono- or dialkylamino, or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino, or
• aryl, heteroaryl, heterocyclyl, —C1-C6 alkyl-aryl, —C1-C6 alkyl-heteroaryl, or —C1-C6 alkyl-heterocyclyl, where the ring portions of each are optionally substituted with 1, 2, 3, or 4 groups independently selected from halogen, —OH, —SH, —C≡N, —NR105R′105, —CO2R, —N(R)COR′, or —N(R)SO2R′, —C(═O)—(C1-C4) alkyl, —SO2-amino, —SO2-mono or dialkylamino, —C(═O)-amino, —C(═O)-mono or dialkylamino, —SO2—(C1-C4) alkyl, or
• —C1-C6 alkoxy optionally substituted with 1, 2, or 3 groups which are independently a halogen, or
• C3-C7 cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, —C1-C6 alkyl and mono- or dialkylamino, or
• C1-C10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF3, —C1-C3 alkoxy, amino, mono- or dialkylamino and —C1-C3 alkyl, or
• C2-C10 alkenyl or C2-C10 alkynyl each of which is optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, C1-C6 alkyl and mono- or dialkylamino;
• and
• the heterocyclyl group is optionally further substituted with oxo;
• R and R′ independently are hydrogen or C1-C10 alkyl;
• R2 is selected from the group consisting of H;
• C1-C6 alkyl, optionally substituted with 1, 2, or 3 substituents that are independently selected from the group consisting of C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, and —NR1-aR1-b;
• wherein
• R1-a and R1-b are —H or C1-C6 alkyl;
• (CH2)0-4-aryl;
• —(CH2)0-4-heteroaryl;
• C2-C6 alkenyl;
• C2-C6 alkynyl;
• —CONRN-2RN-3;
• —SO2NRN-2RN-3;
• —CO2H;
• and —CO2—(C1-C4 alkyl);
• R3 is selected from the group consisting of H;
• C1-C6 alkyl, optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, and —NR1-aR1-b;
• —(CH2)0-4-aryl;
• —(CH2)0-4-heteroaryl;
• C2-C6 alkenyl;
• C2-C6 alkynyl;
• —CO—NRN-2RN-3;
• —SO2—NRN-2RN-3;
• —CO2H;
• and —CO—O—(C1-C4 alkyl);
• or
• R2, R3 and the carbon to which they are attached form a carbocycle of three thru seven carbon atoms, wherein one carbon atom is optionally replaced by a group selected from —O—, —S—, —SO2—, or —NRN-2—;
• RC is selected from the group consisting of C1-C10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from the group consisting of R205, —OC═ONR235R240, —S(═O)0-2 (C1-C6 alkyl), —SH, —NR235C═ONR235R240, —C═ONR235R240, and —S(═O)2NR235R240;
• —(CH2)0-3—(C3-C8) cycloalkyl wherein the cycloalkyl is optionally substituted with 1, 2, or 3 groups independently selected from the group consisting of R205, —CO2H, and —CO2—(C1-C4 alkyl);
• —(CR245R250)0-4-aryl;
• —(CR245R250)0-4-heteroaryl;
• —(CR245R250)0-4-heterocycloalkyl;
• —(CR245R250)0-4-aryl-heteroaryl;
• —(CR245R250)0-4-aryl-heterocycloalkyl;
• —(CR245R250)0-4-aryl-aryl;
• —(CR245R250)0-4-heteroaryl-aryl;
• —(CR245R250)0-4-heteroaryl-heterocycloalkyl;
• —(CR245R250)0-4-heteroaryl-heteroaryl;
• —(CR245R250)0-4-heterocycloalkyl-heteroaryl;
• —(CR245R250)0-4-heterocycloalkyl-heterocycloalkyl;
• —(CR245R250)0-4-heterocycloalkyl-aryl;
• —[C(R255)(R260)]1-3—CO—N—(R255)2;
• —CH(aryl)2;
• —CH(heteroaryl)2;
• —CH(heterocycloalkyl)2;
• —CH(aryl)(heteroaryl);
• cyclopentyl, cyclohexyl, or cycloheptyl ring fused to aryl, heteroaryl, or heterocycloalkyl wherein one carbon of the cyclopentyl, cyclohexyl, or cycloheptyl is optionally replaced with NH, NR215, O, or S(═O)0-2, and wherein the cyclopentyl, cyclohexyl, or cycloheptyl group can be optionally substituted with 1 or 2 groups that are independently R205 or ═O;
• —CO—NR235R240;
• —SO2—(C1-C4 alkyl);
• C2-C10 alkenyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C10 alkynyl optionally substituted with 1, 2, or 3 R205 groups;
• —(CH2)0-1—CH((CH2)0-6—OH)—(CH2)0-1-aryl;
• —(CH2)0-1—CHRC-6—(CH2)0-1-heteroaryl;
• —CH(-aryl or -heteroaryl)—CO—O(C1-C4 alkyl);
• —CH(—CH2—OH)—CH(OH)-phenyl-NO2;
• (C1-C6 alkyl)-O—(C1-C6 alkyl)-OH;
• —CH2—NH—CH2—CH(—O—CH2—CH3)2;
• —H;
• and —(CH2)0-6—C(═NR235)(NR235R240);
• wherein
• each aryl is optionally substituted with 1, 2, or 3 R200;
• each heteroaryl is optionally substituted with 1, 2, 3, or 4 R200;
• each heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 R210;
• R200 at each occurrence is independently selected from the group consisting of C1-C6 alkyl optionally substituted with 1, 2, or 3 R205 groups;
• OH;
• —NO2;
• halogen;
• —CO2H;
• C≡N;
• —(CH2)0-4—CO—NR220R225;
• —(CH2)0-4—CO—(C1-C12 alkyl) ;
• —(CH2)0-4—CO—(C2-C12 alkenyl);
• —(CH2)0-4—CO—(C2-C12 alkynyl);
• —(CH2)0-4—CO—(C3-C7 cycloalkyl);
• —(CH2)0-4—CO-aryl;
• —(CH2)0-4—CO-heteroaryl;
• —(CH2)0-4—CO-heterocycloalkyl;
• —(CH2)0-4—CO2R215;
• —(CH2)0-4—SO2—NR220R225;
• —(CH2)0-4—SO—(C1-C8 alkyl);
• —(CH2)0-4—SO2—(C1-C12 alkyl) ;
• —(CH2)0-4—SO2—(C3-C7 cycloalkyl);
• —(CH2)0-4—N(H or R215)—CO2R215;
• —(CH2)0-4—N(H or R215)—CO—N(R215)2;
• —(CH2)0-4—N—CS—N(R215)2;
• —(CH2)0-4—N(—H or R215)—CO—R220;
• —(CH2)0-4—NR220R225;
• —(CH2)0-4—O—CO—(C1-C6 alkyl) ;
• —(CH2)0-4—O—P(O)—(OR240)2;
• —(CH2)0-4—O—CO—N(R215)2;
• —(CH2)0-4—O—CS—N(R215)2;
• —(CH2)0-4—O—(R215)2;
• —(CH2)0-4—O—(R215)2—COOH;
• —(CH2)0-4—S—(R215)2;
• —(CH2)0-4—O—(C1-C6 alkyl optionally substituted with 1, 2, 3, or 5 —F);
• C3-C7 cycloalkyl;
• C2-C6 alkenyl optionally substituted with 1 or 2 R205 groups;
• C2-C6 alkynyl optionally substituted with 1 or 2 R205 groups;
• —(CH2)0-4—N(H or R215)—SO2—R220;
• and —(CH2)0-4—C3-C7 cycloalkyl;
• wherein each aryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R205, R210 or C1-C6 alkyl substituted with 1, 2, or 3 groups that are independently R205 or R210;
• wherein each heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R210;
• wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R205, R210, or C1-C6 alkyl substituted with 1, 2, or 3 groups that are independently R205 or R210;
• R205 at each occurrence is independently selected from the group consisting of C1-C6 alkyl, halogen, —OH, —O-phenyl, —SH, —C≡N, —CF3, C1-C6 alkoxy, NH2, NH(C1-C6 alkyl), and N—(C1-C6 alkyl)(C1-C6 alkyl);
• R210 at each occurrence is independently selected from the group consisting of C1-C6 alkyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkenyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkynyl optionally substituted with 1, 2, or 3 R205 groups;
• halogen;
• C1-C6 alkoxy;
• C1-C6 haloalkoxy;
• —NR220R225;
• OH;
• C≡N;
• C3-C7 cycloalkyl optionally substituted with 1, 2, or 3 R205 groups;
• —CO—(C1-C4 alkyl);
• _SO2 —NR235R240;
• —CO—NR235R240;
• —SO2—(C1-C4 alkyl);
• and ═O;
• wherein
• R215 at each occurrence is independently selected from the group consisting of C1-C6 alkyl, —(CH2)0-2-(aryl), C2-C6 alkenyl, C2-C6 alkynyl, C3 —C7 cycloalkyl, and —(CH2)0-2-(heteroaryl), —(CH2)0-2- (heterocycloalkyl);
• wherein the aryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R205 or R210;
• wherein the heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 R210;
• wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 R210;
• R220 and R225 at each occurrence are independently selected from the group consisting of —H, —C1-C6 alkyl, hydroxy C1-C6 alkyl, amino C1-C6 alkyl;
• halo C1-C6 alkyl;
• —C3-C7 cycloalkyl, —(C1-C2 alkyl)-(C3-C7 cycloalkyl), —(C1-C6 alkyl)-O—(C1-C3 alkyl), —C2-C6 alkenyl, —C2-C6 alkynyl, —C1-C6 alkyl chain with one double bond and one triple bond, -aryl, -heteroaryl, and -heterocycloalkyl;
• wherein the aryl group at each occurrence is optionally substituted with 1, 2, or 3 R270 groups, wherein
• R270 at each occurrence is independently R205, C1-C6 alkyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkenyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkynyl optionally substituted with 1, 2, or 3 R205 groups;
• halogen;
• C1-C6 alkoxy;
• C1-C6 haloalkoxy;
• NR235R240;
• OH;
• C≡N;
• C3-C7 cycloalkyl optionally substituted with 1, 2, or 3 R205 groups;
• —CO—(C1-C4 alkyl);
• _SO2 —NR235R240;
• —CO—NR235R240;
• —SO2—(C1-C4 alkyl);
• and ═O;
• wherein the heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 R205 groups;
• wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 R205 groups;
• R235 and R240 at each occurrence are independently H, or C1-C6 alkyl;
• R245 and R250 at each occurrence are independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, —(CH2)0-4—C3-C7 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl C1-C4 alkyl, heteroaryl C1-C4 alkyl, and phenyl;
• or
• R245 and R250 are taken together with the carbon to which they are attached to form a carbocycle of 3, 4, 5, 6, or 7 carbon atoms, optionally where one carbon atom is replaced by a heteroatom selected from the group consisting of —O—, —S—, —SO2—, and —NR220—;
• R255 and R260 at each occurrence are independently selected from the group consisting of H;
• C1-C6 alkyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkenyl optionally substituted with 1, 2, or 3 R205 groups;
• C2-C6 alkynyl optionally substituted with 1, 2, or 3 R205 groups;
• —(CH2)1-2—S(O)0-2—(C1-C6 alkyl);
• —(CH2)0-4—C3-C7 cycloalkyl optionally substituted with 1, 2, or 3 R205 groups;
• —(C1-C4 alkyl)-aryl;
• —(C1-C4 alkyl) -heteroaryl;
• —(C1-C4 alkyl)-heterocycloalkyl;
• -aryl;
• -heteroaryl;
• -heterocycloalkyl;
• _(CH2)1-4—R265-(CH2)0-4-aryl;
• —(CH2)1-4—R265—(CH2)0-4-heteroaryl;
• and;
• —(CH2)1-4—R265—(CH2)0-4-heterocycloalkyl;
• wherein
• R265 at each occurrence is independently —O—, —S— or —N(C1-C6 alkyl)-;
• each aryl or phenyl is optionally substituted with 1, 2, or 3 groups that are independently R205, R210, or C1-C6 alkyl substituted with 1, 2, or 3 groups that are independently R205 or R210;
• each heteroaryl is optionally substituted with 1, 2, 3, or 4 R200, each heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 R210.