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US 2003/0166714 A1Published application
Nematicidal compositions and methods
AssigneeDivergence, Inc.
InventorsDeryck Jeremy Williams, Andrew P. Kloek, Michelle Coutu Hresko
Life of this patent
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Abstract
The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes parasitizing animals can also be controlled using the methods and composition of this invention. The useful compounds are inhibitors of nematode delta-12 fatty acid desaturases and can be, for example, from C16 to C20 in length. A feature of these compounds is that their inhibitory effect on the activity of a nematode delta-12 desaturase, or on the viability or fecundity of a nematode, is smaller in the presence of the product of a delta-12 fatty acid desaturase (e.g., linoleate) than in the presence of the substrate of the enzyme (e.g., oleate).
Claims66
A nematicidal composition comprising:
- (a) an effective amount of a compound having the formula
- 6
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- and
- R2=a C15-C19 substituted or unsubstituted carbon chain having a cis double bond between the 9th and 10th carbons and either:
- (i) a triple bond between the 12th and 13th carbons or (ii) either a single or double bond between the 12th and 13th carbons and at least one substituant at one or both of the 12th and 13th carbons, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- and
- (b) an aqueous surfactant.
7 more elements
A nematicidal composition comprising
- (a) a fatty acid methyl ester selected from the group consisting of:
- ricinoleic acid methyl ester, crepenynic acid methyl ester, and vernolic acid methyl ester;
- and
- (b) an aqueous surfactant.
1 more element
A method for control of unwanted nematodes, the method comprising administering to mammals, plants, seeds or soil a nematicidal composition comprising:
- (a) an effective amount of a compound having the formula
- 7
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- and
- R2=a C15-C19 substituted or unsubstituted carbon chain having a cis double bond between the 9th and 10th carbons and either:
- (i) a triple bond between the 12th and 13th carbons or (ii) either a single or double bond between the 12th and 13th carbons and at least one substituant at one or both of the 12th and 13th carbons, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- and
- (b) an aqueous surfactant.
7 more elements
A method for control of unwanted nematodes, the method comprising administering to mammals, plants, seeds or soil a nematicidal composition comprising an effective amount of:
- (a) a fatty acid methyl ester selected from the group consisting of:
- ricinoleic acid methyl ester, crepenynic acid methyl ester, and vernolic acid methyl ester;
- and
- (b) an aqueous surfactant.
1 more element
A nematicidal feed for a non-human mammal comprising:
- (a) a feed;
- (b) an effective amount of a nematicidal compound having the formula
- 8
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- and
- R2=a C15-C19 substituted or unsubstituted carbon chain having a cis double bond between the 9th and 10th carbons and either:
- (i) a triple bond between the 12th and 13th carbons or (ii) either a single or double bond between the 12th and 13th carbons and at least one substituant at one or both of the 12th and 13th carbons, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a singly or multiply or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- and
- (c) an aqueous surfactant.
8 more elements
A nematicidal composition comprising:
- (a) an effective amount of a compound having the formula
- 9
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- R3=a C11 substituted or unsubstituted carbon chain having a cis double bond between the 9th and 10th carbons counting form the carbonyl carbon, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a singly or multiply or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- R4=a C2-C6 substituted or unsubstituted carbon chain wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- X and Y are independently a substituted or unsubstitued methyl or S, provided at least one or X and Y is S and wherein the substituants on the methyl selected from the group consisting of:
- halogen, hydrogen, amino, and hydroxy;
- and
- (b) an aqueous surfactant.
9 more elements
A nematicidal composition comprising;
- (a) an effective amount of a compound having the formula
- 10
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- and
- R2=a C15-C19 substituted or unsubstituted carbon chain having a single bond between the 9th and 10th carbons and either:
- (i) a triple bond between the 12th and 13th carbons or (ii) either a single or double bond between the 12th and 13th carbons and at least one substituant at one or both of the 12th and 13th carbons, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a substituted or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- and(b) an aqueous surfactant.
6 more elements
A nematicidal composition comprising;
- (a) an effective amount of a compound having the formula
- 11
- wherein:
- R1=a C1-C5 substituted or unsubstituted carbon chain, wherein the substituants are selected from the group consisting of:
- hydroxy, halogen, amino, cyano, a singly or multiply substituted or unsubstituted C1-C2 carbon chain, cyclopropane, and epoxy;
- and
- R2=a C15-C19 substituted or unsubstituted carbon chain having a single bond between the 9th and 10th carbons counting form the carbonyl carbon and either:
- (i) a triple bond between the 12th and 13th carbons or (ii) either a single or double bond between the 12th and 13th carbons and at least one substituant at one or both of the 12th and 13th carbons, wherein the substituants are selected from the group consisting of hydroxy, halogen, amino, cyano, a substituted or unsubstituted C1-C2 carbon chain, cyclopropane, cyclopropene, and epoxy;
- and
- (b) an aqueous surfactant.
7 more elements
Dependencies are inferred from the claim text.