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AssigneeDainippon Sumitomo Pharma Co., Ltd.
InventorsToru Kimura, Kaoru Kikuchi, Kazuo Kumagai, Nobuo Hosotani, Akiyoshi Kishino
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To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
A nerve regeneration promoter containing an inhibitor for a nerve outgrowth repelling factor as an active ingredient.
A semaphorin inhibitor containing a compound which has a group represented by formulae [1], [2], [4] or [5] and a group represented by formulae [6] or [7] in the molecule, a pharmaceutically acceptable salt thereof or a derivative thereof, as an active ingredient,
A semaphorin inhibitor containing a compound represented by formula [8], a pharmaceutically acceptable salt thereof or a derivative thereof, as an active ingredient,
A semaphorin inhibitor containing a compound represented by formula [12], a pharmaceutically acceptable salt thereof or a derivative thereof, as an active ingredient,
A compound represented by formula [12], wherein at least one of R1, R2, R4 and R5 is represented by a hydrogen atom, a pharmaceutically acceptable salt thereof or a derivative thereof,
A semaphorin inhibitor containing a compound represented by formula [13], a pharmaceutically acceptable salt thereof or a derivative thereof, as an active ingredient,
A compound represented by formula [13], wherein at least one of R1, R2 and R5 represents a hydrogen atom, a pharmaceutically acceptable salt thereof or a derivative thereof,
A compound represented by formula [14], a pharmaceutically acceptable salt thereof or a derivative thereof,
A compound represented by formula [15], a pharmaceutically acceptable salt thereof or a derivative thereof,
A compound represented by formula [16], a pharmaceutically acceptable salt thereof or a derivative thereof,
Penicillium sp. SPF-3059 (FERM BP-7663) or a fungus strain induced from said SPF-3059.
Dependencies are inferred from the claim text.