New process
AssigneePfizer Inc.
InventorRonald James Ogilvie
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Abstract
The present invention provides an improved process for the preparation of the anti-migraine drug, (R)-5-(2-benzenesulphonylethyl)-3-N-methylpyrrolidin-2-ylmethyl)-1H-indole (eletriptan), available commercially as the hydrobromide salt, and an intermediate and dimer-free products obtained from such process.
Claims23
A process for the preparation of a compound of formula (I)
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- which comprises hydrolysis of a compound of formula (II)
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The compound of formula (II):
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Eletriptan which is substantially free of
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A pharmaceutically acceptable acid addition salt of eletriptan which is substantially free of
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A pharmaceutical composition comprising eletriptan or a pharmaceutically acceptable acid addition salt thereof which is substantially free of
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- and a suitable carrier or excipient.
Dependencies are inferred from the claim text.