Benzene derivatives and pharmaceutical use thereof

Benzene derivatives of the following general formula (I) or pharmaceutically acceptable salts thereof:

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• wherein R1 represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent, R2 represents hydrogen atom or an alkyl group, R3 to R10, which may be the same or different from each other, represent hydrogen atom, a halogen atom, hydroxyl group, mercapto group, nitro group, cyano group, trifluoromethyl group, an alkyl group, an alkoxyl group, an alkylthio group, an amino group which may be substituted with an alkyl group or an amino-protecting group, an acyloxy group, an acyl group, carboxyl group, an alkoxycarbonyl group or carbamoyl group,
• —Y represents a group of following general formula (II), (III) or (IV):
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• wherein R11 and R13 each represent hydrogen atom or an alkyl group, R12 and R14 each represent an alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, a cycloalkenyl group which may have a substituent, an aryl group which may have a substituent, an aromatic heterocyclic group having one or more hetero atom, which may have a substituent, or a saturated heterocyclic group having one or more hetero atoms, which may have a substituent, and R15 and R16 each represent an alkyl group or an aryl group which may form a ring together, and n and m each represent an integer selected from among 0 to 6, and
• —X— represents an interatomic bond, or any of —O—, —O—CHR17—, —CHR18—O—, —O—CO—, —CO—O—, —O—CS—, —CS—O—, —S—, —SO—, —SO2—, —S—CHR19—, —CHR20—S—, —S—CO—, —CO—S—, —S—CS—, —CS—S—, —SO2—NR21—, —NR22—SO2—, —NR23—, —NR24—CHR25—, —CHR26—NR27—, —CO—, —C(═NOR28)—, —C(═CHR29)—, —CO—CHR30—, —CHR31—CO —, —CO—NR32—, —NR33—CO—, —CR34R35—, —CHR36—CHR37— and —CR38═CR39— wherein R17, R18, R19, R20, R21, R22, R25, R26, R29, R30, R31, R32, R33, R34, R38 and R39 each represent hydrogen atom or an alkyl group, R23, R24, R27 and R28 each represent hydrogen atom, an alkyl group or an acyl group, R36 and R37 each represent hydrogen atom, hydroxyl group or an alkyl group, and R35 represents hydrogen atom, hydroxyl group, mercapto group, cyano group, an alkyl group which may have a substituent, an alkoxyl group, an alkylthio group, an acyloxy group, an amino group which may be substituted with an alkyl group or an amino-protecting group, carboxyl group, an alkoxycarbonyl group or carbamoyl group.