Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
AssigneeBiovitrum AB
InventorsGuido Kurz, Marianne Nilsson
Life of this patent
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Abstract
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Claims14
A compound of the formula (I):
- 3
- wherein
- T is selected from
- thienyl substituted with one or more of bromo, chloro;
- phenyl substituted as follows:
- a) either T is phenyl, wherein the phenyl is substituted with one or more of propyl and phenyl;
- b) T is phenyl substituted with chloro in position 3 and methyl in position 2;
- c) T is phenyl substituted with chloro in position 2 and 4, and methyl in position 6;
- d) T is phenyl substituted with bromo in position 4 and fluoro in position 2 and 5;
- e) T is phenyl substituted with chloro in position 2,3, and 4;
- f) T is phenyl substituted with chloro in position 2,4, and 5;
- g) T is phenyl substituted with bromo in position 4 and methyl in position 2;
- h) T is phenyl substituted with chloro in position 2 and 6;
- i) T is phenyl substituted with chloro in position 2,4, and 6;
- or
- j) T is phenyl substituted with bromo in position 4 and chloro in position 5.
- A is selected from an aryl ring or heteroaryl ring, which can further be optionally substituted in one or more positions independently of each other by hydrogen, C1-6-alkyl, halogenated C1-6-alkyl, halogen, C1-6-alkoxy, nitro, C1-6-alkoxycarbonyl, C1-6-alkylsulfonyl, acetylamino or aryloxy, wherein the aryloxy can further be optionally substituted in one or more positions independently of each other by hydrogen and halogen;
- B is selected from hydrogen and C1-6-alkoxycarbonyl or is linked to A to give a 6-membered aromatic or non-aromatic ring;
- as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
A method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, depression, virus diseases and inflammatory disorders and to achieve immuno-modulation, said method comprising administering to a mammal, including man, in need of such treatment an effective amount of a compound of the formula (I)
- 4
- wherein
- T is an aryl ring or heteroaryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, halogen, C1-6-alkyl, and aryl;
- A is selected from an aryl ring or heteroaryl ring, which can further be optionally substituted in one or more positions independently of each other by hydrogen, C1-6-alkyl, halogenated C1-6-alkyl, halogen, C1-6-alkoxy, nitro, C1-6-alkoxycarbonyl, C1-6-alkylsulfonyl, acetylamino or aryloxy, wherein the aryloxy can further be optionally substituted in one or more positions independently of each other by hydrogen and halogen;
- B is selected from hydrogen and C1-6-alkoxycarbonyl or is linked to A to give a 6-membered aromatic or non-aromatic ring;
- as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
The use of a compound of the formula (I)
- 5
- wherein
- T is an aryl ring or heteroaryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, halogen, C1-6-alkyl and aryl;
- A is selected from an aryl ring or heteroaryl ring, which can further be optionally substituted in one or more positions independently of each other by hydrogen, C1-6-alkyl, halogenated C1-6-alkyl, halogen, C1-6-alkoxy, nitro, C1-6-alkoxycarbonyl, C1-6-alkylsulfonyl, acetylamino or aryloxy, wherein the aryloxy can further be optionally substituted in one or more positions independently of each other by hydrogen and halogen;
- B is selected from hydrogen and C1-6-alkoxycarbonyl or is linked to A to give a 6-membered aromatic or non-aromatic ring;
- as well as pharmaceutically acceptable salts, hydrates and solvates thereof,
- in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, depression, virus diseases and inflammatory disorders and to achieve immuno-modulation.
Dependencies are inferred from the claim text.