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US 2003/0166678 A1Published application
Carboxylated heterocyclic compounds and methods of synthesis
AssigneeR.T. Alamo Ventures I, LLC
InventorsStefan Kwiatkowski, Miroslaw Golinski
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Abstract
Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
Claims3
A composition comprising 3-carboxymethylsulfinyl-7-fluoro-3-methyl-4-quinolone having the corresponding structure:
- 8
A method, comprising:
- a) providing:
- i) 3-cyanomethylthio-7-fluoro-1-methyl-4-quinolone;
- and
- ii) a first acid;
- b) reacting said 3-cyanomethylthio-7-fluoro-1-methyl-4-quinolone and said first acid under conditions such that 3-carboxymethylthio-7-fluoro-1-methyl-4-quinolone is produced.
2 more elements
Dependencies are inferred from the claim text.