US 2003/0166673 A1 · Medicines for the prevention and treatment of neurodegenerative diseases

Abstract

Medicines for the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease and schizophrenia of mammals (including human beings) through the retardation or inhibition of neurodegeneration due to hypofunction of glutamic acid receptor and which contain as an active ingredient 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives of the formula (I): 1 wherein Het is oxadiazolyl; R1 is hydrogen, lower alkyl, cyclo-lower alkyl, lower alkenyl, lower alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, etc.; and R2 is hydrogen, lower alkyl, cyclo-lower alkyl, substituted or unsubstituted aryl, etc., or physiologically acceptable acid addition salts thereof.

Claims12

Dependent claims

A medicine for prevention and treatment of neurodegenerative diseases comprising a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative of the following formula (I):

4
wherein:
Het is an oxadiazolyl group;
R1 is a hydrogen atom, a lower alkyl group, a cyclo-lower alkyl group, a trifluoromethyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkoxy-lower alkyl group, a hydroxy-lower alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group;
and
R2 is a hydrogen atom, a lower alkyl group, a cyclo-lower alkyl group, a cyclo-lower alkylmethyl group, a lower alkenyl group, a cyclo-lower alkenyl group, a lower alkynyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group,
or a physiologically acceptable acid addition salt thereof.

4 more elements

Dependencies are inferred from the claim text.

Medicines for the prevention and treatment of neurodegenerative diseases

Life of this patent

Medicines for the prevention and treatment of neurodegenerative diseases

Life of this patent

Abstract

Claims12