Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof
AssigneeSuper Gen, Inc.
InventorsSanjeev Redkar, Ashok Gore
Life of this patent
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Abstract
Amorphous forms of 9-nitrocamptothecin are provided by grinding or pulverizing different polymorphic forms of 9-nitrocamptothecin, and the polymorphic forms are characterizable as having an X-ray powder diffraction pattern with discernable diffraction lines at different °2θ values for Cu Kα radiation having a wavelength of 1.5406 Angstrom.
Claims36
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 6.7, 12.5, 14.0 and 23.9 for Cu Kα radiation of wavelength 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 4.8, 14.2, 19.1 and 26.8 for Cu Kα radiation of wavelength of 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 11.0, 14.0, 16.4, and 27.0 for Cu Kα radiation of wavelength of 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 5.4, 10.6 and 26.5 for Cu Kα radiation having a wavelength of 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 10.5, 12, 13.25, 16.0, and 24.5 for Cu Kα radiation having a wavelength of 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 7.4 and 22.5 for Cu Kα radiation having a wavelength of 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by grinding or pulverizing a polymorphic form of 9-nitrocamptothecin, wherein the polymorphic form is characterizable as having an X-ray powder diffraction pattern with diffraction lines at °2θ values 8.0 and 25.7 for Cu Kα radiation of wavelength 1.5406 Angstrom.
An amorphous form of 9-nitrocamptothecin produced by removing methanol by evaporation from a 9-nitrocamptothecin in methanol solution.
Dependencies are inferred from the claim text.