Indole derivatives useful for the treatment of CNS disorders

A substituted indole derivative of formula I

• 11
• wherein R1 is hydrogen or C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl or C3-8-cycloalkyl-C1-6-alkyl, all of which may be substituted one or more times with substituents selected from halogen, cyano, nitro, amino, hydroxy, thiol, C1-6-alkoxy, C1-6-alkylthio, trifluoromethyl, trifluoromethylsulfonyl and C1-6-alkylsulfonyl, or R1 is aryl, aryl-C1-6-alkyl, heteroaryl, heteroaryl-C1-6-alkyl where the aryl and heteroaryl groups may be substituted one or more times with substituents selected from halogen, cyano, nitro, amino, C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, thiol, trifluoromethyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl, or R1 is —NR′R″ wherein R′ and R″ are independently selected from hydrogen and C1-6-alkyl, aryl, aryl-C1-6-alkyl, heteroaryl and heteroaryl-C1-6-alkyl, all of which may be substituted one or more times with substituents selected from halogen, cyano, nitro, amino, C1-6-alkyl, C1-6alkoxy, C1-6-alkylthio, hydroxy, thiol, trifluoromethyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl, or R1 is a saturated or partially saturated 5- to 6-membered ring containing one, two or three hetero atoms selected from O or S, and a group N—R9 wherein R9 is hydrogen or C1-6-alkyl optionally substituted with substituents selected from halogen, cyano, nitro, amino, C1-6-alkoxy, C1-6-alkylthio, hydroxy, thiol, trifluoromethyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl;
• W is a bond or an O, S, CO, CS, SO or SO2 group;
• n is 0-6, m is 0-6 and n+m is 0-6;
• provided that when W is O or S, n≧2, and when W is CO, CS, SO or SO2, n≧1;
• X is C, CH or N and the dotted line emanating from X indicates a bond when X is C and no bond when X is N or CH;
• R2 is C1-6-alkyl;
• R3-R7 are selected from hydrogen, halogen, cyano, nitro, amino, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, thiol, trifluoromethyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl;
• R8 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, aryl, aryl-C1-6-alkyl, acyl, thioacyl, C1-6-alkylsulfonyl, trifluoromethylsulfonyl, or arylsulfonyl or a pharmaceutically acceptable acid addition salt thereof.