Therapeutic or preventive medicines for mood disorders or anxiety disorders
OwnerHiroshi Nagase, Toshiaki Tanaka +1inventors
InventorsHiroshi Nagase, Toshiaki Tanaka, Akiyoshi Saitoh
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Abstract
A drug for curing or preventing mood disorder or anxiety disorder that has fewer and milder side effects comprising, as an effective component, an isoquinoline derivative or a physiologically acceptable acid addition salt thereof, the representative example of the isoquinoline derivative being (4aS, 12aS)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydroquinolino [2,3-g]isoquinoline; a method for curing or preventing mood disorder or anxiety disorder using the same; and a use of the isoquinoline derivative or the physiologically acceptable acid addition salt thereof for the manufacture of a medicament for curing or preventing mood disorder and anxiety disorder.
Claims12
A drug for curing or preventing mood disorder or anxiety disorder, comprising an effective amount of an isoquinoline derivative represented by formula (I) or a physiologically acceptable acid addition salt thereof:
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- wherein R1 is hydrogen, C1-C5 alkyl, C4-C7 cycloalkylalkyl, C5-C7 cycloalkenylalkyl, C7-C14 aralkyl, C4-C5 trans-alkenyl, allyl, furan-2-ylalkyl (C-1-C5), thien-2-ylalkyl (C1-C5), C1-C5 alkanoyl, benzoyl, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, or C8-C14 arylalkanoyl;
- R2 is hydrogen or OR6 (wherein R6 is hydrogen, C1-C5 alkyl, or C1-C5 alkanoyl);
- R3 and R3′ are, independently, C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, C1-C5 alkoxy, nitro, amino, C1-C3 alkylamino;, or C2-C6 dialkylamino;
- R4 is hydrogen, hydroxy, C1-C3 alkoxy, benzyloxy, C1-C5 alkanoyloxy, chlorine, fluorine, bromine, or iodine;
- X is nitrogen or carbon;
- R5 exists only when X is carbon and is C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, C1-C5 alkoxy, nitro, amino, C1-C3 alkylamino, or C2-C6 dialkylamino.
A method for curing or preventing mood disorder or anxiety disorder comprising administering an effective amount of an isoquinoline derivative represented by formula (I) or a physiologically acceptable acid addition salt thereof:
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- wherein R1 is hydrogen, C1-C5 alkyl, C4-C7 cycloalkylalkyl, C5-C7 cycloalkenylalkyl, C7-C14 aralkyl, C4-C5 trans-alkenyl, allyl, furan-2-ylalkyl (C1-C5), thien-2-ylalkyl (C1-C5), C1-C5 alkanoyl, benzoyl, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, or C8-C14 arylalkanoyl;
- R2 is hydrogen or OR6 (wherein R6 is hydrogen, C1-C5 alkyl, or C1-C5 alkanoyl);
- R3 and R3 are, independently, C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, C1-C5 alkoxy, nitro, amino, or C1-C3 alkylamino;
- R4 is hydrogen, hydroxy, C1-C3 alkoxy, benzyloxy, C1-C5 alkanoyloxy, or halogen;
- X is nitrogen or carbon;
- R5 exists only when X is carbon and is C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, C1-C5 alkoxy, nitro, amino, or C1-C3 alkylamino.
A use of an isoquinoline derivative represented by formula (I) or a physiologically acceptable acid addition salt thereof for the manufacture of a medicament for curing or preventing mood disorder or anxiety disorder:
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- wherein R1 is hydrogen, C1-C5 alkyl, C4-C7 cycloalkylalkyl, C5-C7 cycloalkenylalkyl, C7-C14, aralkyl, C4-C5 trans-alkenyl, allyl, furan-2-ylalkyl (C1-C5), thien-2-ylalkyl (C1-C5), C1-C5 alkanoyl, benzoyl, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, or C8-C14 arylalkanoyl;
- R2 is hydrogen or OR6 (wherein R6 is hydrogen, C1-C5 alkyl, or C1-C5 alkanoyl);
- R3 and R3 are, independently, C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, Cl-C5 alkoxy, nitro, amino, or C1-C3 alkylamino;
- R4 is hydrogen, hydroxy, C1-C3 alkoxy, benzyloxy, C1-C5 alkanoyloxy, or halogen;
- X is nitrogen or carbon;
- R5 exists only when X is carbon and is C1-C5 alkyl, hydrogen, chlorine, fluorine, bromine, iodine, trifluoromethyl, cyano, hydroxy, C1-C3 alkoxycarbonyl, C1-C3 alkylcarbonylamino, C1-C5 alkoxy, nitro, amino, or C1-C3 alkylamino.
Dependencies are inferred from the claim text.