Chemical compounds

A compound of formula (I):

• 17
• wherein:
• m and n are, independently, 0, 1, 2, 3 or 4;
• X is CH2, CO, O, S, S(O), S(O)2 or NR6;
• Y is NR4S(O)2R5 or S(O)2NR4R5;
• T is C═O or CR7R8;
• R1 is hydrogen, C1-6 alkyl, aryl or heterocyclyl;
• R2 and R3 are, independently, hydrogen or C1-6 alkyl;
• R4 and R6 are, independently, hydrogen or C1-6 alkyl (optionally substituted with aryl);
• R5 is C1-6 alkyl {optionally substituted by halogen, CO2R11, aryl or heterocyclyl}, C3-10 cycloalkyl {optionally substituted by C1-4 alkyl or oxo}, C3-7 cycloalkenyl {optionally substituted by C1-6 alkyl or aryl}, aryl or heterocyclyl;
• or, when Y is S(O)2NR4R5, R5 may also be hydrogen;
• R7, R8, R9 and R10 are, independently, hydrogen or C1-6 alkyl (optionally substituted with aryl);
• wherein the foregoing aryl and heterocyclyl moieties are, independently, optionally substituted by one or more of halo, cyano, nitro, hydroxy, S(O)qR11, OCONR12R13, NR14R15, NR16COR7, NR18CONR19R20,SO2NR21R22, NR23SO2R24, CONR25R26, COR27, CO2R28, OCOR29, NR30CO2R31, C1-6 alkyl (itself optionally substituted with halo, C1-6 alkoxy, C3-10 cycloalkyl, CO2(C1-6 alkyl), OCO(C1-6 alkyl), SO2R32, CONR33R34, phenyl, phenoxy, heterocyclyl or heterocyclyloxy), C3-10 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, methylenedioxy, phenyl, phenoxy, phenylthio, phenyl(C1-4)alkoxy, heterocyclyl, heterocyclyloxy or heterocyclyl(C1-4)alkoxy;
• wherein any of the immediately foregoing phenyl and heterocyclyl moieties are optionally substituted with halo, hydroxy, nitro, S(O)kC1-4 alkyl, SO2NH2, cyano, C1-4 alkyl, C1-4 alkoxy, CONH2, CONH(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), NHCO(C1-4 alkyl), NHSO2(C1-4 alkyl), CO(C1-4 alkyl), CF3 or OCF3;
• R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R25, R26, R27, R28, R29, R30, R31, R33 and R34 are, independently, hydrogen, C1-6 alkyl or aryl (itself optionally substituted by halo, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy);
• R11, R24 and R32 are, independently, C1-6 alkyl or aryl (itself optionally substituted by halo, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy);
• k and q are, independently, 0, 1 or 2;
• or a pharmaceutically acceptable salt thereof;
• or a solvate thereof.