Dihydro-benzo[b][1,4]diazepin-2-one derivatives

A compound of formula

• 17
• wherein
• X is a single bond or an ethynediyl group;
• and wherein in case X is a single bond,
• R1
• is hydrogen,
• cyano,
• halogen,
• lower alkyl,
• lower alkoxy,
• fluoro-lower alkyl,
• fluoro-lower alkoxy,
• pyrrol-1-yl, or
• phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl;
• or in case X is an ethynediyl group,
• R1 is phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl;
• and wherein
• R2
• is hydrogen,
• lower alkyl,
• lower alkenyl
• lower alkoxy,
• halogen,
• —NR′R″,
• pyrrolidin-1-yl,
• piperidin-1-yl,
• morpholine-4-yl,
• fluoro-lower alkyl,
• fluoro-lower alkoxy, or
• lower alkoxy-(ethoxy)m;
• m is 1, 2, 3 or 4;
• R′ is hydrogen, lower alkyl or C3-C6-cycloalkyl;
• R″ is hydrogen, lower alkyl or C3-C6-cycloalkyl;
• Y is —CH═ or ═N—;
• R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide, which rings are unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, —(CH2)n—C(O)—OR″, —(CH2)n—C(O)—NR′R″, —(CH2)n—SO2—NR′R″, —(CH2)n—C(NH2)═NR″, hydroxy, lower alkoxy, lower alkylthio, C3-C6-cycloalkyl and lower alkyl, which is optionally substituted by fluoro, —NR′R″, hydroxy, lower alkoxy, pyrrolidin-1-yl, azetidin-1-yl, cyano or carbamoyloxy, whereby R′ and R″ have the meaning specified above;
• n is 0, 1, 2, 3 or 4;
• or a pharmaceutically acceptable addition salt thereof.