Technical field

A chemical compound represented by the general formula (I):

• 21
• in which formula (I),
• o is 0, 1, 2 or 3;
• R1 represents an alkyl group, a phenyl group, or a monocyclic heterocyclic group, which groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, alkoxy, halogen, trifluoromethyl, cyano, amino, and nitro;
• or R1 represents a cyano group, or a group of the formula -alkyl-CO2R2, alkenyl-CO2R2, —CO—R2, —CO2(CH2)mR2, or —C(R3)═N—OR2, in which formulas
• m is 0, 1, 2 or 3;
• R2 and R3 independently represents hydrogen, alkyl, alkenyl, alkynyl, phenyl, benzyl, a 5- or 6-membered heterocyclic group, which 5- or 6-membered heterocyclic group may optionally be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, amino, or nitro;
• or R2 and R3 may independently represent a group of the formula —(CH2)q—NR4R5, —(CH2)q,CON(R4R5), —(CH2)q—CO2R4, or -alkyl-CO2R4, in which formulas
• R4 and R5 independently represent hydrogen or alkyl;
• and
• q is 0, 1, 2 or 3;
• R11 represents a group of the general formula —CO2—R9, wherein
• R9 represents hydrogen or alkyl, which alkyl may optionally be substituted with a 5- or 6-membered heterocyclic group, which 5- or 6-membered heterocyclic group may optionally be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, amino, or nitro;
• or R9 may be a 5- or 6-membered heterocyclic group, which 5- or 6-membered heterocyclic group may optionally be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, amino, or nitro;
• or R9 represent a group of the general formula -alkyl-N(R1OR12), in which formula
• R10 and R12 independently represent hydrogen or alkyl;
• or R11 represents a group of general formula (II):
• 22
• in which formula (11),
• n is 0, 1, 2, or 3;
• R′ and R″ each independently represents hydrogen or alkyl;
• or R′ and R″ together with the N atom to which they are attached form a 5- to 7-membered heterocyclic ring, which heterocyclic ring may optionally comprise as a ring member, one oxygen atom, and/or one additional nitrogen atom, and/or a —CH═CH— chain;
• and in which formula the 5- to 7-membered heterocyclic ring formed by R′ and R″ may optionally be substituted one ore more times with a group of the formula —(CH2)pX, wherein
• p is O, 1, 2 or 3;
• X represents hydrogen, hydroxy, alkyl or alkenyl, which alkyl and alkenyl may optionally be substituted one or more, times with a group of the formula —CO2R6;
• or X represents a group of the formula —CO—R6, —CO2—R6, —CON—R6R7, or —COO—R6—NR7R8, in which formulas
• R6, R7 and R8 independently represents hydrogen or alkyl;
• or R11 may represent a group of the general formula (III):
• 23
• in which formula (III),
• n is 0, 1, 2 or 3;
• R′ is hydrogen or alkyl;
• R′″ and R″″ together with the atoms to which they are attached form a 5- to 7-membered heterocyclic ring, which heterocyclic ring may optionally comprise as a ring member, one oxygen atom, and/or one additional nitrogen atom, and/or a —CH═CH— chain;
• and in which formula the 5- to 7-membered heterocyclic ring formed by R′″ and R″″ may optionally be substituted one ore more times with a group of the formula —(CH2)pX, wherein
• p is 0, 1, 2 or 3;
• X represents hydrogen, hydroxy, alkyl or alkenyl, which alkyl and alkenyl may optionally be substituted one or more times with a group of the formula —CO2R6;
• or X represents a group of the formula —CO—R6, —CO2—R6, —CON—R6R7, or —COO—R6—NR7R11, in which formulas
• R6, R7 and R8 independently represents hydrogen or alkyl;
• or a pharmaceutically acceptable salt thereof of an oxide thereof.