Pharmaceutical compositions and methods for administering EP2 receptor selective agonists

A method for treating a bone fracture, bone injury or bone defect in a patient comprising local administration to the patient of a therapeutically effective amount of an EP2 receptor selective agonist in a controlled release formulation;

• wherein the agonist is administered in an oily suspension of an insoluble salt of the agonist;
• wherein the agonist is administered in a bone glue formulation;
• wherein the agonist is administered in a hydrophilic matrix containing poloxamers;
• wherein the agonist is administered in controlled-release, biodegradable lipid vessicles;
• wherein the agonist is administered in controlled-release, biodegradable poly(lactide-co-glycolide) microparticles;
• wherein the agonist is administered in a polyanionic polysaccharide formulation;
• wherein the agonist is administered in high viscosity liquid carrier material or lower viscosity liquid carrier material;
• wherein the agonist is administered in carbonated apatite or hydroxyapatite formulation and a biocompatible source of calcium;
• wherein the agonist is administered in collagen-containing carrier preparation;
• or
• wherein the agonist is administered in formulations of thrombin, fibrin or synthetic peptides derived therefrom.