Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents

A compound of Formula I

• 19
• including pharmaceutically acceptable salts thereof in which
• g is 0, 1, 2, 3, 4 or 5;
• n is 2 or 3;
• R1 is a) halo, b) an alkyl group containing 1 to 3 carbon atoms optionally substituted by one or more halo, c) an alkoxy group containing 1 to 3 carbon atoms optionally substituted by one or more halo, d) an alkylthio group, an alkylsulphinyl group or an alkylsulphonyl group each containing 1 to 3 carbon atoms optionally substituted by one or more halo, e) hydroxy, f) an acyloxy group containing 1 to 3 carbon atoms, g) a hydroxyalkyl group containing 1 to 3 carbon atoms, h) cyano, i) an alkanoyl group containing 1 to 6 carbon atoms, j) an alkoxycarbonyl group containing 2 to 6 carbon atoms, k) a carbamoyl group or a carbamoylmethyl group each optionally N-substituted by one or two alkyl groups each containing 1 to 3 carbon atoms, l) a sulphamoyl or sulphamoylmethyl group each optionally N-substituted by one or two alkyl groups each containing 1 to 3 carbon atoms, or m) an amino group optionally substituted by one or two alkyl groups each containing 1 to 3 carbon atoms;
• R1 being the same or different when g is 2, 3, 4 or 5;
• R2 represents H, an alkyl group containing 1 to 6 carbon atoms optionally substituted by one or more halo, a hydroxyalkyl group containing 1 to 6 carbon atoms, an α-hydroxyarylmethyl group, a hydroxyalkenyl group containing 3 to 6 carbon atoms in which hydroxy is not attached directly to either carbon of the double bond, a hydroxyalkynyl group containing 3 to 6 carbon atoms in which hydroxy is not attached directly to either carbon of the triple bond, a hydroxycycloalkyl group containing 3 to 6 carbon atoms, an alkenyl group containing 2 to 8 carbon atoms, an arylalkenyl group containing 8 to 10 carbon atoms, a cycloalkyl group containing 3 to 6 carbon atoms, a C3-4alkynylalkoxyC1-3alkyl group, a C4-6cycloalkylalkoxyC1-3alkyl group, a C1-3alkoxyC1-3alkyl group, a C1-3alkylthioC1-3alkyl group, a C1-3alkoxy group, a C1-3alkylthio group, an arylthio group, a C1-6 alkanoyl group, a C3-6 alkoxycarbonylalkyl group, cyano, halo, a C1-4alkyliminomethyl group, a C1-4alkylaminoalkyl group or a hydroxyiminomethyl group;
• and
• wherein the condensed thiazole ring may be attached at the 2, 4, 5, 6 or 7-position of the benzothiophene ring with the proviso that when the condensed thiazole ring is attached at the 2-position or the 5-position of the benzothiophene ring and g is 0 then R2 is not H, and with the further proviso that when the condensed thiazole ring is attached at the 2-position of the benzothiophene ring and g is other than 0 then R, is not attached at the 3-position of the benzothiophene ring.