Penetration enhancing and irritation reducing systems
AssigneeCellegy Pharmaceuticals, Inc.
InventorsVivien H.W. Mak, Stephen Grayson
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Abstract
This invention lies in the technology of transdermal and topical drug delivery. In particular, the present invention relates to enhancement of the penetration of transdermally or topically applied drugs and with the reduction of skin irritation that often accompanies transdermal and topical drug delivery.
Claims45
A composition for topical application having penetration- enhancing properties comprising:
- a) an active agent;
- and
- b) a penetration-enhancing system comprising:
- (i) oleic acid;
- (ii) a C1-C4 alcohol;
- and
- (iii) a glycol.
A method for administering a topically or systemically active agent, said method comprising:
- topically administering to a mammal a composition comprising:
- a) said active agent;
- and b) a penetration-enhancing system comprising:
- (i) a membrane fluidizer;
- (ii) a C1-C4 alcohol;
- and (iii) a glycol.
A method for reducing inflammation associated with topical application of a topicallly or systemically active agent, said method comprising:
- topically administering to a mammal a composition comprising:
- a) said active agent;
- b) a penetration-enhancing system comprising:
- (i) a membrane fluidizer;
- (ii) a C1-C4 alcohol;
- and (iii) a glycol.
Dependencies are inferred from the claim text.