Synergistic compositions for the selective control of tumor tissue
OwnerWerner Kreutzinventor
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Abstract
According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
Claims48
A synergistic composition comprising a mixture of at least two benzoic acid derivatives selected from
- 2-acetoxybenzoic acid (acetylsalicylic acid)
- 2-hydroxybenzoic acid
- 2-methoxybenzoic acid
- 2,4-dihydroxybenzoic acid
- 2,4-diacetoxybenzoic acid
- 2-hydroxy-4-aminobenzoic acid
- 2,4-dimethoxybenzoic acid
- 2,6-dihydroxybenzoic acid
- 2,6-dimethoxybenzoic acid
- 2,3,4-trimethoxybenzoic acid
- 2,4,6-trihydroxybenzoic acid
- 2,4,6-trimethoxybenzoic acid
- 5-(2,4-difluoro-phenyl)salicylic acid
- α-cyano-3-hydroxycinnamic acid
- α-cyano-4-hydroxycinnamic acid
- α-fluorocinnamic acid
- α-methylcinnamic acid and
- α-acetamidocinnamic acid.
A pharmaceutical pack consisting of two medicaments each comprising at least one benzoic acid derivative selected from
- 2-acetoxybenzoic acid (acetylsalicylic acid)
- 2-hydroxybenzoic acid
- 2-methoxybenzoic acid
- 2,4-dihydroxybenzoic acid
- 2,4-diacetoxybenzoic acid
- 2-hydroxy-4-aminobenzoic acid
- 2,4-dimethoxybenzoic acid
- 2,6-dihydroxybenzoic acid
- 2,6-dimethoxybenzoic acid
- 2,3,4-trimethoxybenzoic acid
- 2,4,6-trihydroxybenzoic acid
- 2,4,6-trimethoxybenzoic acid
- 5-(2,4-difluoro-phenyl)salicylic acid
- α-cyano-3-hydroxycinnamic acid
- α-cyano-4-hydroxycinnamic acid
- α-fluorocinnamic acid
- α-methylcinnamic acid and
- α-acetamidocinnamic acid
- for joined or timely shifted administration, wherein the pharmaceutical pack comprises at least two different benzoic acid derivatives.
Composition comprising 5-(2,4-difluorophenyl)salicylic acid and at least one other salicylic acid derivative.
Pharmaceutical pack consisting of two medicaments wherein one medicament comprises 5-(2,4-difluoro-phenyl)salicylic acid and the other medicament comprises at least one other salicylic acid derivative for joint or timely shifted administration.
Dependencies are inferred from the claim text.