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US 2003/0166603 A1Published application
Methods and compositions for the diagnosis and treatment of cancer
AssigneeBoard of Regents, The University of Texas System
InventorGary L. Clayman
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Abstract
Methods for the treatment of squamous cell carcinoma using a p53-expressing viral vector are disclosed. In particular embodiments, the vector is a replication-deficient adenovirus. In addition, there are provided methods for examining the development and treatment of microscopic residual disease in the context of post-surgical environments and in body cavities.
Claims25
A method for treating a subject with a malignancy comprising the steps of:
- (a) providing an expression construct comprising a promoter functional in eukaryotic cells and a polynucleotide encoding a p53, wherein said polynucleotide is positioned sense to and under the control of said promoter;
- and
- (b) contacting said expression construct with a tumor cell in vivo.
A method for determining the effectiveness of a therapy on microscopic residual cancer comprising:
- (a) providing a rodent with an incision into subcutaneous tissue;
- (b) seeding said incision with tumor cells;
- (c) treating said rodent with a therapeutic regimen;
- and
- (d) assessing the impact of said regimen on the development of tumors.
2 more elements
Dependencies are inferred from the claim text.