Targeted drug delivery with a CD44 receptor ligand
AssigneeThe Regents of the University of California
InventorFrancis C. Szoka JR.
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Abstract
The invention is a drug delivery system of a delivery vehicle having a low molecular weight hyaluronan ligand with an affinity for CD44 receptors. Preferably, the delivery vehicle is a liposome but other suitable delivery vehicles include micropspheres, micelles, emulsions, lipid discs, polymers, viral particles and viruses. The systems of the invention may further comprise a drug, which can be any anticancer agent or other therapeutic or diagnostic agent. The invention also comprises methods of delivering a drug to a cell that expresses CD44 by contacting the cell with the drug delivery system. Further methods include treating a patient with cancer and targeting drug delivery to cells that express CD44 by attaching a glycosaminoglycan ligand.
Claims35
A drug delivery system comprising a delivery vehicle having a low molecular weight hyaluronan ligand with an affinity for CD44 receptors.
A method for delivering a drug to a cell expressing the CD44 receptor comprising the step of contacting the cell with a composition comprising the drug and a delivery vehicle, wherein the delivery vehicle has a hyaluronan ligand having an affinity for CD44 receptors.
A method for treating a patient with cancer characterized by tumor cells that express the CD44 receptor, comprising the step of administering a composition comprising an anticancer drug and a delivery vehicle, wherein the delivery vehicle has a glycosaminoglycan ligand having an affinity for CD44 receptors.
A method for diagnosing a patient with cancer characterized by tumor cells that express the CD44 receptor, comprising the step of administering a composition comprising a diagnostic reagent drug and a delivery vehicle, wherein the delivery vehicle has a glycosaminoglycan ligand having an affinity for CD44 receptors.
A method for delivering a drug to a cell expressing CD44 receptors comprising the steps of targeting a composition of a delivery vehicle and the drug to the cell by attaching a glycosaminoglycan ligand having an affinity for CD44 receptors and administering the composition.
Dependencies are inferred from the claim text.