US 2003/0166599 A1 · Uses of tgap7 for the modulation of leucocyte activation

Abstract

Described are pharmaceutical compositions comprising polynucleotides encoding TGAP7 protein or a biologically fragment thereof. Furthermore, pharmaceutical compositions are described which comprise vectors comprising the aforementioned polynucleotides and/or host cells transformed therewith. Additionally, pharmaceutical compositions comprising antisense constructs to be aforementioned polynucleotides are described. Furthermore, methods and uses for modulating immune responses through the TGAP7 protein as well as pharmaceutical compositions comprising agents which act on the TGAP7 protein are described. Also, the use of said polynucleotide, vector, protein or antibody for the preparation of diagnostic and pharmaceutical compositions for use, inter alia, in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided.

Claims22

Dependent claims

A pharmaceutical composition comprising a polynucleotide encoding a TGAP7 protein or a biologically active fragment thereof comprising a nucleic acid molecule selected from the group consisting of

(i) DNA sequences comprising a nucleotide sequence encoding the amino acid sequence depicted in SEQ ID NO:
2 or 4;
(ii) DNA sequences comprising the nucleotide sequence depicted in SEQ ID NO:1 or 3;
(iii) DNA sequences comprising a nucleotide sequence encoding a fragment or derivative of the protein encoded by the DNA sequence of (i) or (ii);
(iv) DNA sequences the complementary strand of which hybridizes with and which is at least 70% identical to the polynucleotide as defined in any one of (i) to (iii);
and
(v) DNA sequences the nucleotide of which is degenerate to the nucleotide sequence of a DNA sequence of any one of (i) to (iv).

4 more elements

Dependencies are inferred from the claim text.

Uses of tgap7 for the modulation of leucocyte activation

Life of this patent

Uses of tgap7 for the modulation of leucocyte activation

Life of this patent

Abstract

Claims22