Antisense modulation of liver glycogen phosphorylase expression
OwnerBrett P. Monia, Lex M. Cowsertinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of liver glycogen phosphorylase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding liver glycogen phosphorylase. Methods of using these compounds for modulation of liver glycogen phosphorylase expression and for treatment of diseases associated with expression of liver glycogen phosphorylase are provided.
Claims51
An antisense compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding liver glycogen phosphorylase, wherein said antisense compound specifically hybridizes with and inhibits the expression of liver glycogen phosphorylase.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding liver glycogen phosphorylase.
A method of modulating an insulin-signaling pathway in an animal comprising administering to said animal a therapeutically or prophylactically effective amount of an inhibitor of liver glycogen phosphorylase.
Dependencies are inferred from the claim text.