Loading patent…
OwnerJohn R. Wetterau II, Daru Young Sharp +7inventors
InventorsJohn R. Wetterau II, Daru Young Sharp, Richard E. Gregg, Scott A. Biller, John K. Dickson, R. Michael Lawrence, John E. Lawson, Henry M. Holava, Richard A. Partyka
Estimating the term…
Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
An isolated nucleic acid molecule comprising a nucleic acid sequence coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, wherein the nucleic acid sequence coding for part of the high molecular weight subunit of microsomal triglyceride transfer protein is at least about 15 sequential nucleotides in length.
A prokaryotic or eukaryotic host cell comprising the expression vector according to claim 10.
A method for producing a polypeptide molecule having all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, which comprises culturing a host cell according to claim 11 under conditions permitting expression of the polypeptide.
A method for producing a polypeptide molecule having all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, which comprises culturing a host cell according to claim 12 under conditions permitting expression of the polypeptide.
A method for detecting a nucleic acid sequence coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein or a related nucleic acid sequence, which comprises:
An isolated polypeptide molecule comprising at least five sequential amino acids of the high molecular weight subunit of microsomal triglyceride transfer protein.
A process for detecting an inhibitor of microsomal triglyceride transfer protein comprising:
A method for preventing, stabilizing or causing regression of atherosclerosis in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein.
A method for decreasing serum lipid levels in a mammalian species, which comprises administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein.
A method for preventing or treating pancreatitis in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein.
A method for preventing or treating obesity in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein.
A compound of the formula
A compound of the formula
A compound of the formula
Dependencies are inferred from the claim text.