Method and pharmaceutical composition for the treatment of multiple sclerosis
OwnerNathan Karininventor
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Abstract
Methods and pharmaceutical compositions are disclosed, effective in breaking-down immunological tolerance the CXC chemokine interferon gamma-inducible protein 10 (IP-10), resulting in the generation of self specific immunity to IP-10, for the treatment of diseases, such as autoimmune diseases, in which IP-10 plays a pivotal role in disease onset and/or progression, e.g., in multiple sclerosis (MS).
Claims54
A method of breaking-down an immunological tolerance to interferon gamma-inducible protein 10 in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to break-down the immunological tolerance to interferon gamma-inducible protein 10.
A method of generating self specific immunity to interferon gamma-inducible protein 10 in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to generate self specific immunity to interferon gamma-inducible protein 10.
A method of preventing or treating an autoimmune disease in which activity of interferon gamma-inducible protein 10 is pivotal in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to treat or prevent the autoimmune disease.
A method of restricting a polarization of myelin basic protein specific T cells into Th2 cells in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to restrict a polarization of myelin basic protein specific T cells into Th2 cells.
A method of inducing protective immunity against multiple sclerosis in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies, so as to induce protective immunity against multiple sclerosis in the subject.
A method of preventing or treating multiple sclerosis in a subject, the method comprising administering to, or expressing within, the subject an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to treat or prevent multiple sclerosis.
A pharmaceutical composition for breaking-down an immunological tolerance to interferon gamma-inducible protein 10 in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to break-down the immunological tolerance to interferon gamma-inducible protein 10.
A pharmaceutical composition for generating self specific immunity to interferon gamma-inducible protein 10 in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to generate self specific immunity to interferon gamma-inducible protein 10.
A pharmaceutical composition for preventing or treating an autoimmune disease in which activity of interferon gamma-inducible protein 10 is pivotal in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to treat or prevent the autoimmune disease.
A pharmaceutical composition for restricting a polarization of myelin basic protein specific T cells into Th2 cells in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to restrict a polarization of myelin basic protein specific T cells into Th2 cells.
A pharmaceutical composition for inducing protective immunity against multiple sclerosis in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies, so as to induce protective immunity against multiple sclerosis in the subject.
A pharmaceutical composition for preventing or treating multiple sclerosis in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, an amount of interferon gamma-inducible protein 10, or an immunological portion thereof, or of an expression construct encoding said interferon gamma-inducible protein 10, or said immunological portion thereof, sufficient to elicit sufficient anti-interferon gamma-inducible protein 10 antibodies so as to treat or prevent multiple sclerosis.
A method of breaking-down an immunological tolerance to interferon gamma-inducible protein 10 in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to break-down the immunological tolerance to interferon gamma-inducible protein 10.
A method of generating specific immunity to interferon gamma-inducible protein 10 in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to generate self specific immunity to interferon gamma-inducible protein 10.
A method of preventing or treating an autoimmune disease in which activity of interferon gamma-inducible protein 10 is pivotal in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to treat or prevent the autoimmune disease.
A method of restricting a polarization of myelin basic protein specific T cells into Th2 cells in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to restrict a polarization of myelin basic protein specific T cells into Th2 cells.
A method of inducing protective immunity against multiple sclerosis in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to induce protective immunity against multiple sclerosis in the subject.
A method of preventing or treating multiple sclerosis in a subject, the method comprising administering to the subject anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to treat or prevent multiple sclerosis.
A pharmaceutical composition for breaking-down an immunological tolerance to interferon gamma-inducible protein 10 in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to break-down the immunological tolerance to interferon gamma-inducible protein 10.
A pharmaceutical composition for generating self specific immunity to interferon gamma-inducible protein 10 in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to generate self specific immunity to interferon gamma-inducible protein 10.
A pharmaceutical composition for preventing or treating an autoimmune disease in which activity of interferon gamma-inducible protein 10 is pivotal in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to treat or prevent the autoimmune disease.
A pharmaceutical composition for restricting a polarization of myelin basic protein specific T cells into Th2 cells in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to restrict a polarization of myelin basic protein specific T cells into Th2 cells.
A pharmaceutical composition for inducing protective immunity against multiple sclerosis in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to induce protective immunity against multiple sclerosis in the subject.
A pharmaceutical composition for preventing or treating multiple sclerosis in a subject, the pharmaceutical composition comprising, a pharmaceutically acceptable carrier approved for medical or veterinary administration and, as an active ingredient, anti-interferon gamma-inducible protein 10 antibodies in an amount sufficient to treat or prevent multiple sclerosis.
A method of breaking-down an immunological tolerance to interferon gamma-inducible protein 10 in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to break-down the immunological tolerance to interferon gamma-inducible protein 10.
A method of generating specific immunity to interferon gamma-inducible protein 10 in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to generate self specific immunity to interferon gamma-inducible protein 10.
A method of preventing or treating an autoimmune disease in which activity of interferon gamma-inducible protein 10 is pivotal in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to treat or prevent the autoimmune disease.
A method of restricting a polarization of myelin basic protein specific T cells into Th2 cells in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to restrict a polarization of myelin basic protein specific T cells into Th2 cells.
A method of inducing protective immunity against multiple sclerosis in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to induce protective immunity against multiple sclerosis in the subject.
A method of preventing or treating multiple sclerosis in a subject, the method comprising directly or indirectly introducing anti-interferon gamma-inducible protein 10 antibodies to the subject in an amount sufficient to treat or prevent multiple sclerosis.
Dependencies are inferred from the claim text.