Substituted tetracycline compounds as synergistic antifungal agents
AssigneeParatek Pharmaceuticals, Inc.
InventorsMichael Draper, Mark L. Nelson
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Abstract
Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
Claims76
A method for increasing the antifungal activity of an antifungal agent, comprising administering said antifungal agent in combination with an effective amount of a substituted tetracycline compound, such that the antifungal activity of said antifungal agent is increased.
A method for treating a fungal associated disorder in a subject, comprising administering to said subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that said subject is treated for said fungal associated disorder.
A method for treating a fungal associated disorder in a mammal, comprising administering to said mammal a synergistically effective amount of a substituted tetracycline compound in combination with an effective amount amphotericin B, such that said mammal is treated for said fungal associated disorder.
A pharmaceutical composition comprising a synergistically effective amount of a substituted tetracycline compound, an effective amount of an antifungal agent, and a pharmaceutically acceptable carrier.
A method of killing fungus, comprising contacting said fungus with a synergistically effective amount of a substituted tetracycline compound and a effective amount of an antifungal agent, such that said fungus is killed.
Dependencies are inferred from the claim text.