Aryl fused azapolycyclic compounds

A compounds of formula (I)

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• wherein R1 is independently hydrogen or —COOR4 wherein R4 is a group of formula
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• R2 and R3, together with the benzo ring to which they are attached, form a bicyclic ring system selected from the following:
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• wherein one of the carbon atoms of ring A can optionally be replaced with oxygen or N(C1-C6)alkyl;
• wherein R11 and R12 are selected, independently, from hydrogen, (C1-C6)alkyl;
• and (C1-C6)alkoxy-(C0-C6)alkyl- wherein the total number of carbon atoms does not exceed six and wherein any of the alkyl moieties may optionally be substituted with from one to seven fluorine atoms;
• nitro, cyano, halo, amino, (C1-C6)alkylamino-, ((C1-C6)alkyl)2amino-, —CO2R5, —CONR6R7, —SO2NR8R9, —C(═O)R10, —XC(═O)R11, phenyl, monocyclic heteroaryl, or when attached to a nitrogen atom, a group of formula:
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• each R5, R6, R7, R8, R9 and R10 is selected, independently, from hydrogen and (C1-C6)alkyl, or
• R6 and R7, or R8 and R9 together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, morpholine, azetidine, piperazine, —N—(C1-C6)alkylpiperazine or thiomorpholine ring, or a thiomorpholine ring wherein the ring sulfur is replaced with a sulfoxide or sulfone;
• and each X is, independently, (C1-C6)alkylene;
• with the proviso that when R1 is H, then at least one of R11 or R12 must be a group of formula:
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• attached to a nitrogen atom in the ring formed by groups R2 and R3, and forming an ammonium ion center on that nitrogen atom if necessary to accommodate the existing bonding relationships;
• and pharmaceutically acceptable salts thereof.