2-Amino-3-hydroxy-4-tert-leucyl-amino-5 phenyl-pentanoic acid amide derivatives

A compound of formula I

• 12
• wherein
• n is 0 or 1;
• R1 and R2 are independently of the other an aliphatic radical, or an aromatic, aromatic-aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, heterocyclic or heterocyclic-aliphatic radical, each radical having not more than 20 carbon atoms;
• R3 is hydrogen, oxa-alkyl, an aliphatic radical or a radical with up to 20 carbon atoms of the formula —(Y)m—R6, wherein Y is alkyl, m is 0 or 1 and R6 is an unsubstituted or substituted monocyclic radical with 5 or 6 ring members containing up to 3 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur, wherein said monocyclic radical can also be fused to a benzo ring;
• R4 and R5 are independently selected from the group consisting of hydrogen;
• an aliphatic radical;
• free, etherified or esterified hydroxy;
• free or esterified carboxy;
• formyl;
• alkanoyl;
• unsubstituted, mono- or di-substituted amino;
• mercapto;
• sulfo;
• alkyl-thio;
• carbamoyl;
• N-alkyl-carbamoyl;
• N,N-di-alkyl-carbamoyl;
• cyano and nitro;
• wherein carbon containing radicals R4 and R5 have up to 12 carbon atoms, with the proviso that R4 and R5 are not both hydrogen if n is 1, R1 is benzyl or tert-butyl, R2 is benzyl or 4-methoxy-benzyl, R3 is isopropyl and X is oxygen and that R4 is not methoxy if n is 0 or 1, R2 is 4-methoxy-benzyl, R3 is isopropyl or tert-butyl, R5 is hydrogen and X is oxygen;
• and
• X is nitrogen, oxygen or sulfur;
• or a salt thereof.