Nociceptin-based analgesics
AssigneeSynvax, Inc.
InventorAmrit K. Judd
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Abstract
The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be constructed having modifications or substitutions at any position, and may include modifications of the amino- and carboxy-termini of the hexapeptide. These compounds include agents exhibiting agonist activity and antagonist activity when exposed to the human ORL-1 receptor. As such, the hexapeptides may be useful as analgesics, anxiolytics, diuretics, and anti-cancer agents.
Claims66
A hexapeptide of the formula:
- Arg-Xaa-Tyr-Arg-Trp-Arg (SEQ ID NO:
- 17), wherein the hexapeptide binds with the ORL-1 receptor, wherein xaa is selected from the group consisting of natural amino acids, D-amino acids, non-natural amino acids, modified natural amino acids, and amino acid analogs.
A hexapeptide of the formula:
- Arg-Tyr-Xaa-Arg-Trp-Arg (SEQ ID NO:
- 18), wherein the hexapeptide binds with the ORL-1 receptor, wherein Xaa is selected from the group consisting of natural amino acids, D-amino acids, non-natural amino acids, modified natural amino acids, and amino acid analogs.
A hexapeptide of the formula:
- Xaa1-Tyr-Tyr-Xaa2-Trp-Xaa3 (SEQ ID NO:
- 19), wherein the hexapeptide binds with the ORL-1 receptor, wherein Xaa is selected from the group consisting of natural amino acids, D-amino acids, non-natural amino acids, modified natural amino acids, and amino acid analogs.
A hexapeptide of the formula:
- Arg-Tyr-Tyr-Arg-Xaa-Arg (SEQ ID NO:
- 27), wherein the hexapeptide binds with the ORL-1 receptor, wherein Xaa is selected from the group consisting of natural amino acids, D-amino acids, non-natural amino acids, modified natural amino acids, and amino acid analogs.
Dependencies are inferred from the claim text.