Peptide and its use in the treatment of hyperpigmentation conditions
OwnerAnthony J. Thody, John M. Wood +1inventors
InventorsAnthony J. Thody, John M. Wood, Karin U. Schallreuter
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Abstract
A peptide having the formula: X—N(H)-A1-B2-C3-D4-Lys5-Lys6-Arg7-C(O)—Y wherein A, B, C and D are amino acid residues; X is selected from the group consisting of H, a pharmaceutically acceptable amine blocking group and, together with Y, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1; and Y is selected from the group consisting of OH, a pharmaceutically acceptable carboxyl blocking group and, together with X, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1. Such peptides may be used topically to treat hyperpigmentation conditions such as melanism and melasma.
Claims15
A peptide having the formula:
- X—N(H)-A1-B2-C3-D4-Lys5-Lys6-Arg7-C(O)—Y
- wherein
- A, B, C and D are amino acid residues;
- X is selected from the group consisting of H, a pharmaceutically acceptable amine blocking group and, together with Y, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1;
- and
- Y is selected from the group consisting of oh, a pharmaceutically acceptable carboxyl blocking group and, together with X, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1.
A therapeutic composition comprising a pharmacologically acceptable concentration of a peptide having the formula:
- X—N(H)-A1-B2C3-D4-Lys5-Lys6-Arg7-C(O)—Y
- wherein
- A, B, C and D are amino acid residues;
- X is selected from the group consisting of H, a pharmaceutically acceptable amine blocking group and, together with Y, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1;
- and
- Y is selected from the group consisting of OH, a pharmaceutically acceptable carboxyl blocking group and, together with X, a covalent bond connecting the carbonyl group of Arg7to the amine group of A1;
- and a therapeutically acceptable vehicle.
A method for the treatment or prophylaxis of a hyperpigmentation condition in mammals by administration of a therapeutically effective amount of a composition comprising a peptide having the formula:
- X—N(H-A1-B2-C3-D4-Lys5-Lys6-Arg7-C(O)—Y
- wherein
- A, B, C and D are amino acid residues;
- X is selected from the group consisting of H, a pharmaceutically acceptable amine blocking group and, together with Y, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1;
- and
- Y is selected from the group consisting of OH, a pharmaceutically acceptable carboxyl blocking group and, together with X, a covalent bond connecting the carbonyl group of Arg7 to the amine group of A1;
- and a therapeutically acceptable vehicle.
Dependencies are inferred from the claim text.