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US 2003/0166569 A1Published application
Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
AssigneeNymox Pharmaceutical Corporation
InventorsPaul Averback, Jack Gemmell
Life of this patent
Estimating the term…
Abstract
The invention is directed to methods of treating conditions requiring removal or destruction of harmful or unwanted cells in a patient, such as benign and malignant tumors, using compounds containing or based on peptides comprising a part of the amino acid sequence of a neural thread protein.
Claims35
A peptide comprising at least one NTP peptide selected from the group consisting of:
- a) The peptide represented by the amino acid sequence in SEQ ID NO. 8 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu);
- b) The peptide represented by the amino acid sequence in SEQ ID NO. 9 (Met-Met-Val-Cys-Trp-Asn-Arg-Phe-Gly-Lys-Trp-Val-Tyr-Phe-Ile);
- c) The peptide represented by the amino acid sequence in SEQ ID NO. 10 (Ser-Ala-Ile-Phe-Asn-Phe-Gly-Pro-Arg-Tyr-Leu-Tyr-His-Gly-Val);
- d) The peptide represented by the amino acid sequence in SEQ ID NO. 11 (Pro-Phe-Tyr-Phe-Leu-Ile-Leu-Val-Arg-Ile-Ile-Ser-Phe-Leu-Ile);
- e) The peptide represented by the amino acid sequence in SEQ ID NO. 12 (Gly-Asp-Met-Glu-Asp-Val-Leu-Leu-Asn-Cys-Thr-Leu-Leu-Lys-Arg);
- f) The peptide represented by the amino acid sequence in SEQ ID NO. 13 (Ser-Ser-Arg-Phe-Arg-Phe-Trp-Gly-Ala-Leu-Val-Cys-Ser-Met-Asp);
- g) The peptide represented by the amino acid sequence in SEQ ID NO. 14 (Ser-Cys-Arg-Phe-Ser-Arg-Val-Ala-Val-Thr-Tyr-Arg-Phe-Ile-Thr);
- h) The peptide represented by the amino acid sequence in SEQ ID NO. 15 (Leu-Leu-Asn-Ile-Pro-Ser-Pro-Ala-Val-Trp-Met-Ala-Arg-Asn-Thr);
- i) The peptide represented by the amino acid sequence in SEQ ID NO. 16 (Met-Ala-Gln-Ser-Arg-Leu-Thr-Ala-The-Ser-Ala-Ser-Arg-Val-Gln);
- j) The peptide represented by the amino acid sequence in SEQ ID NO. 17 (Ala-Ile-Leu-Leu-Ser-Gln-Pro-Pro-Lys-Gln-Leu-Gly-Leu-Arg-Ala);
- k) The peptide represented by the amino acid sequence in SEQ ID NO. 18 (Pro-Ala-Asn-Thr-Pro-Leu-Ile-Phe-Val-Phe-Ser-Leu-Glu-Ala-Gly);
- l) The peptide represented by the amino acid sequence in SEQ ID NO. 19 (Phe-His-His-Ile-Cys-Gln-Ala-Gly-Leu-Lys-Leu-Leu-Thr-Ser-Gly);
- m) The peptide represented by the amino acid sequence in SEQ ID NO. 20 (Asp-Pro-Pro-Ala-Ser-Ala-Phe-Gln-Ser-Ala-Gly-Ile-Thr-Gly-Val);
- n) The peptide represented by the amino acid sequence in SEQ ID NO. 21 (Ser-His-Leu-Thr-Gln-Pro-Ala-Asn-Leu-Asp-Lys-Lys-Ile-Cys-Ser);
- o) The peptide represented by the amino acid sequence in SEQ ID NO. 22 (Asn-Gly-Gly-Ser-Cys-Tyr-Val-Ala-Gln-Ala-Gly-Leu-Lys-Leu-Leu-Ala-Ser-Cys-Asn-Pro-Ser-Lys);
- p) The peptide represented by the amino acid sequence in SEQ ID NO. 23 (Met-Trp-Thr-Leu-Lys-Ser-Ser-Leu-Val-Leu-Leu-Leu-Cys-Leu-Thr);
- q) The peptide represented by the amino acid sequence in SEQ ID NO. 24 (Cys-Ser-Tyr-Ala-Phe-Met-Phe-Ser-Ser-Leu-Arg-Gln-Lys-Thr-Ser);
- r) The peptide represented by the amino acid sequence in SEQ ID NO. 25 (Glu-Pro-Gln-Gly-Lys-Val-Pro-Cys-Gly-Glu-His-Phe-Arg-Ile-Arg);
- s) The peptide represented by the amino acid sequence in SEQ ID NO. 26 (Gln-Asn-Leu-Pro-Glu-His-Thr-Gln-Gly-Trp-Leu-Gly-Ser-Lys-Trp);
- t) The peptide represented by the amino acid sequence in SEQ ID NO. 27 (Leu-Trp-Leu-Leu-Phe-Ala-Val-Val-Pro-Phe-Val-Ile-Leu-Lys-Cys);
- u) The peptide represented by the amino acid sequence in SEQ ID NO. 28 (Gln-Arg-Asp-Ser-Glu-Lys-Asn-Lys-Val-Arg-Met-Ala-Pro-Phe-Phe);
- v) The peptide represented by the amino acid sequence in SEQ ID NO. 29 (Leu-His-His-Ile-Asp-Ser-Ile-Ser-Gly-Val-Ser-Gly-Lys-Arg-Met-Phe);
- w) The peptide represented by the amino acid sequence in SEQ ID NO. 30 (Glu-Ala-Tyr-Tyr-Thr-Met-Leu-His-Leu-Pro-Thr-Thr-Asn-Arg-Pro);
- x) The peptide represented by the amino acid sequence in SEQ ID NO. 31 (Lys-Ile-Ala-His-Cys-Ile-Leu-Phe-Asn-Gln-Pro-His-Ser-Pro-Arg);
- y) The peptide represented by the amino acid sequence in SEQ ID NO. 32 (Ser-Asn-Ser-His-Ser-His-Pro-Asn-Pro-Leu-Lys-Leu-His-Arg-Arg);
- z) The peptide represented by the amino acid sequence in SEQ ID NO. 33 (Ser-His-Ser-His-Asn-Arg-Pro-Arg-Ala-Tyr-Ile-Leu-Ile-Thr-Ile);
- aa) The peptide represented by the amino acid sequence in SEQ ID NO. 34 (Leu-Pro-Ser-Lys-Leu-Lys-Leu-Arg-Thr-His-Ser-Gln-Ser-His-His);
- bb)The peptide represented by the amino acid sequence in SEQ ID NO. 35 (Asn-Pro-Leu-Ser-Arg-Thr-Ser-Asn-Ser-Thr-Pro-Thr-Asn-Ser-Phe-Leu-Met-Thr-Ser-Ser-Lys-Pro-Arg);
- cc) The peptide represented by the amino acid sequence in SEQ ID NO. 36 (Ser-Ser-Ser-Leu-Gly-Leu-Pro-Lys-Cys-Trp-Asp-Tyr-Arg-His-Glu);
- dd) The peptide represented by the amino acid sequence in SEQ ID NO. 37 (Leu-Leu-Ser-Leu-Ala-Leu-Met-Ile-Asn-Phe-Arg-Val-Met-Ala-Cys);
- ee) The peptide represented by the amino acid sequence in SEQ ID NO. 38 (Thr-Phe-Lys-Gln-His-Ile-Glu-Leu-Arg-Gln-Lys-Ile-Ser-Ile-Val);
- ff) The peptide represented by the amino acid sequence in SEQ ID NO. 39 (Pro-Arg-Lys-Leu-Cys-Cys-Met-Gly-Pro-Val-Cys-Pro-Val-Lys-Ile);
- gg)The peptide represented by the amino acid sequence in SEQ ID NO. 40 (Ala-Leu-Leu-Thr-Ile-Asn-Gly-His-Cys-Thr-Trp-Leu-Pro-Ala-Ser);
- hh)The peptide represented by the amino acid sequence in SEQ ID NO. 41 (Met-Phe-Val-Phe-Cys-Leu-Ile-Leu-Asn-Arg-Glu-Lys-Ile-Lys-Gly);
- ii) The peptide represented by the amino acid sequence in SEQ ID NO. 42 (Gly-Asn-Ser-Ser-Phe-Phe-Leu-Leu-Ser-Phe-Phe-Phe-Ser-Phe-Gln);
- jj) The peptide represented by the amino acid sequence in SEQ ID NO. 43 (Asn-Cys-Cys-Gln-Cys-Phe-Gln-Cys-Arg-Thr-Thr-Glu-Gly-Tyr-Ala);
- kk)The peptide represented by the amino acid sequence in SEQ ID NO. 44 (Val-Glu-Cys-Phe-Tyr-Cys-Leu-Val-Asp-Lys-Ala-Ala-Phe-Glu-Cys-Trp-Trp-Phe-Tyr-Ser-Phe-Asp-Thr);
- ll) The peptide represented by the amino acid sequence in SEQ ID NO. 45 (Met-Glu-Pro-His-Thr-Val-Ala-Gln-Ala-Gly-Val-Pro-Gln-His-Asp);
- mm) The peptide represented by the amino acid sequence in SEQ ID NO. 46 (Leu-Gly-Ser-Leu-Gln-Ser-Leu-Leu-Pro-Arg-Phe-Lys-Arg-Phe-Ser);
- nn)The peptide represented by the amino acid sequence in SEQ ID NO. 47 (Cys-Leu-Ile-Leu-Pro-Lys-Ile-Trp-Asp-Tyr-Arg-Asn-Met-Asn-Thr);
- and
- oo) The peptide represented by the amino acid sequence in SEQ ID NO. 48 (Ala-Leu-Ile-Lys-Arg-Asn-Arg-Tyr-Thr-Pro-Glu-Thr-Gly-Arg-Lys-Ser).
39 more elements
Dependencies are inferred from the claim text.