Organic compounds
OwnerFranz Kricek, Andreas Nechansky +1inventors
InventorsFranz Kricek, Andreas Nechansky, Michael Robertson
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Abstract
Screening assay and methods comprising peptide PREKY for the identification of ligands, and ligands identified by such assay, which interfere with cell activation induced via FcεRIα, e.g. which inhibit mast cell/basophil activation.
Claims10
A screening assay for the identification of a ligand that interferes with cell activation induced via FcεRIα, comprising peptide amino acid sequence PREKY as a molecular target.
A method of identifying a ligand to peptide amino acid sequence PREKY comprising
- contacting a candidate compound with a molecular target comprising peptide amino acid sequence PREKKY,
- determining if said candidate compound is bound to peptide amino acid sequence PREKY,
- isolating the ligand bound to peptide amino acid sequence PREKY, and
- identifying the candidate compound.
A method for identifying an FcεRIα ligand that interferes with allergen-induced and FcεRIα-mediated cell activation, comprising providing a selection matrix comprising peptide amino acid sequence PREKY in a fluid environment in the presence of a candidate compound, determining whether said candidate compound binds to said selection matrix, identifying a candidate compound which binds to said selection matrix, and isolating the ligand which binds to said selection matrix.
Dependencies are inferred from the claim text.