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US 2003/0166566 A1Published application
Chemically modified novel erythropoietin stimulating protein compositions and methods
AssigneeAmgen Inc.
InventorsOlaf Kinstler, Colin Gegg, Aimee Freeman, Thomas Boone
Life of this patent
Estimating the term…
Abstract
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
Claims13
A substantially homogenous preparation of chemically modified NESP, optionally in a pharmaceutically acceptable diluent, carrier or adjuvant.
A pharmaceutical composition comprising:
- (a) a substantially homogenous preparation of mono-PEGylated NESP, said mono-PEGylated NESP consisting of a polyethylene glycol moiety connected to a NESP moiety solely at the N-terminus thereof;
- (b) fewer than 5% non-pegylated NESP molecules;
- and
- (c) a pharmaceutically acceptable diluent, adjuvant or carrier.
1 more element
A pharmaceutical composition comprising:
- (a) a substantially homogenous preparation of mono-PEGylated NESP, said mono-PEGylated NESP consisting of a polyethylene glycol moiety connected to a NESP moiety through aldehydes generated in said NESP carbohydrate chains;
- (b) fewer than 5% non-pegylated NESP molecules;
- and
- (c) a pharmaceutically acceptable diluent, adjuvant or carrier.
1 more element
A pharmaceutical composition comprising:
- (a) a substantially homogenous preparation of mono-PEGylated NESP, said mono-PEGylated NESP consisting of a polyethylene glycol moiety connected to a NESP moiety using methoxy-PEG-NHS chemistry;
- (b) fewer than 5% non-pegylated NESP molecules;
- and
- (c) a pharmaceutically acceptable diluent, adjuvant or carrier.
1 more element
A pharmaceutical composition comprising:
- (a) a substantially homogenous preparation of PEGylated NESP, said PEGylated NESP comprising a mixed population of mono-PEGylated NESP and poly-PEGylated NESP;
- (b) fewer than 5% non-pegylated NESP molecules;
- and
- (c) a pharmaceutically acceptable diluent, adjuvant or carrier.
1 more element
Dependencies are inferred from the claim text.