Fusion protein delivery system and uses thereof
AssigneeUniversity of Alabama Research Foundation
InventorsJohn C. Kappes, Xiaoyun Wu
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Abstract
The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
Claims8
A fusion protein comprising:
- a first polypeptide sequence corresponding to a portion of a protein functioning in replication of a virus;
- and
- a second polypeptide sequence corresponding to a virus inhibitory protein fragment, said fragment being sufficient to inhibit replication of said virus.
A fusion protein comprising:
- a first polypeptide sequence corresponding to a fragment of a viral protein;
- and
- a second polypeptide sequence differing from said first sequence and corresponding to a protein fragment, said fragment coupled to said first sequence.
Dependencies are inferred from the claim text.