Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
AssigneeThe Gov't of USA as represented by the Secretary of the Department of Health and Human Services
InventorMichael R. Boyd
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Abstract
The present invention provides, among other things, methods of removing virus from a sample, a composition comprising a solid support matrix to which is attached a cyanovirin, a conjugate comprising a cyanovirin coupled to at least one effector component, a composition comprising such a conjugate, methods of inhibiting prophylactically or therapeutically a viral infection of a host, and a matrix-anchored anti-cyanovirin antibody.
Claims9
A method of inhibiting prophylactically or therapeutically a viral infection of a host, which method comprises administering to said host an antiviral effective amount of a conjugate comprising an isolated and purified antiviral protein or antiviral peptide comprising at least nine contiguous amino acids of SEQ ID NO:
- 2, wherein said at least nine contiguous amino acids bind to a virus, coupled to an anti-cyanovirin antibody or at least one effector component, which can be the same or different, selected from the group consisting of polyethylene glycol, dextran and albumin, whereupon administration of said antiviral effective amount of said conjugate, said viral infection is inhibited.
A method of inhibiting prophylactically or therapeutically a viral infection of a host, which method comprises topically administering to a host an antiviral effective amount of a composition comprising an isolated and purified antiviral agent selected from the group consisting of an antiviral protein, an antiviral peptide, an antiviral protein conjugate, and an antiviral peptide conjugate, wherein (i) said antiviral protein or antiviral peptide comprises at least nine contiguous amino acids of SEQ ID NO:
- 2, (ii) said at least nine contiguous amino acids of SEQ ID NO:
- 2 have antiviral activity, and (iii) said antiviral protein, antiviral peptide, antiviral protein conjugate or antiviral peptide conjugate is attached to a solid support matrix, whereupon administration of said antiviral effective amount of said composition, said viral infection is inhibited.
A matrix-anchored anti-cyanovirin antibody, wherein said antibody binds to an epitope of an antiviral protein or an antiviral peptide comprising at least nine contiguous amino acids of SEQ ID NO:
- 2 and wherein said antibody is attached to a solid-support matrix.
Dependencies are inferred from the claim text.