Targeting peptides
OwnerKlaus Schughart, Ulla Rasmussen +1inventors
InventorsKlaus Schughart, Ulla Rasmussen, Valerie Schreiber
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Abstract
The present invention relates to targeting peptides and more specifically peptides that target heart and various tumors as well as to their use for targeting. The present invention also provides a composition comprising at least one therapeutic agent and at least one peptide of the invention or, alternatively, a nucleic acid molecule encoding such a peptide as well as its use for the preparation of a drug intended for gene transfer.
Claims12
A peptide selected from the group consisting of:
- X1CNDIGWVRCX2
- X1CWPYPSHFCX2
- X1MPLPQPSHLPLLX2
- X1LPQRAFWVPPIVX2
- X1WPVRPWMPGPVVX2
- X1WPTSPWLEREPAX2
- X1WPTSPWSSRDWSX2
- X1HEWSYLAPYPWFX2
- X1QIDRWFDAVQWLX2
- X1CLPSTRWTCX2
- X1CWPMKSX5FCX2
- wherein each X1
- and X2 independently of one another represents any amino acid sequence of n amino acids, n varying from 0 to 50 and n being identical or different in X1 and X2, and wherein X5 represents any amino acid.
A tumor targeting peptide comprising at least a three amino acid motif selected from the group consisting of:
- (i) NDI, WPY, MPL, PSH, LPQ, WPV or WPT or any combination thereof, and
- (ii) HEW, QID, WPM or CLP or any combination thereof.
Dependencies are inferred from the claim text.