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AssigneeBoard of Regents, The University of Texas System
InventorsJohnny W. Peterson, Shamsher S. Saini, Thomas G. Wood, Ashok K. Chopra
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Synthetic milittin and related peptides derived from the sequence of human phospholipase A2-activating protein (PLAP), free from the contaminating phospholipase A2 (PLA2) and/or present when the peptides are purified from natural sources, show inhibitory activity against PLA2. Inhibition of this enzyme, responsible for the hydrolysis of arachiodonate, an important precursor of eicosanoids, should lead to a decrease in the inflammatory response. In addition to their use as anti-inflammatory therapeutics, compositions containing the synthetic peptides may also be useful therapeutic tools for diagnosing inflammatory diseases (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis).
Synthetic melittin, peptide G22R, peptide G23, peptide G24, peptide G25, peptide G26, peptide G27, peptide G141, peptide G142, peptide F31, or peptide F32 usable for the treatment of a disease characterized by a undesirable inflammatory response.
A method of treating a disease characterized by an undesired inflammatory response comprising administering a composition containing synthetic melittin, peptide G22R, peptide G23, peptide G24, peptide G25, peptide G26, peptide G27, peptide G141, peptide G142, peptide F31, or peptide F32 at an appropriate dosage.
A method of purifying PLA2 using a composition containing synthetic melittin peptide G22R, peptide G23, peptide G24, peptide G25, peptide G26, peptide G27, peptide G141, peptide G142, peptide F31, or peptide F32.
A method of diagnosing a disease characterized by the presence of PLA2 comprising detecting PLA2 with compositions containing synthetic melittin peptide G22R, peptide G23, peptide G24, peptide G25, peptide G26, peptide G27, peptide G141, peptide G142, peptide F31, or peptide F32.
A diagnostic test based on detection of the unique amino acid sequence of human PLAP.
A polynucleotide having SEQ ID No. 1.
A protein coded by the polynucleotide of SEQ ID No. 1.
A peptide having SEQ ID No. 2.
A peptide having SEQ ID No. 3
A peptide having SEQ ID No. 4.
A peptide having SEQ ID No. 5.
A peptide having SEQ ID No. 6.
A peptide having SEQ ID No. 7.
A peptide having SEQ ID No. 8.
A peptide having SEQ ID No. 9.
A peptide having SEQ ID No. 10.
A peptide having SEQ ID No. 11.
A peptide having SEQ ID No. 12.
A peptide having SEQ ID No. 13.
Dependencies are inferred from the claim text.