VEGF-D and angiogenic use thereof
AssigneeChiron Corporation
InventorSalvatore Oliviero
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Abstract
The present invention is directed to a method of inducing angiogenesis in a tissue in need of angiogenesis, comprising providing the tissue in need of angiogenesis with an angiogenically effective amount of a recombinant c-fos induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D), which is secreted factor of the VEGF family which binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3 (VEGF-D). In another aspect, the present invention is directed to a method of inducing angiogenesis in an area in need of angiogenesis in a mammal comprising administering to said area in need of angiogenesis an angiogenically effective amount VEGF-D. The VEGF-D is provided or administered in solution of slow release form.
Claims22
A method for inducing angiogenesis in a tissue comprising providing a tissue in need of angiogenesis with an angiogenically effective amount of a recombinant VEGF-D or an angiogenically active fragment or mutein thereof.
A method for inducing angiogenesis in an area in need of angiogenesis in a mammal comprising providing the area in need of angiogenesis with an angiogenically effective amount of a recombinant VEGF-D or an angiogenically active fragment or mutein thereof.
Dependencies are inferred from the claim text.