Systemic immune response induced by mucosal administration of lipid-tailed polypeptides without adjuvant
AssigneeInstitut Pasteur
InventorsPierre Druilhe, Helene Grasmasse, Lbachir Benmohamed
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Abstract
A lipopeptide, compositions containing the lipopeptide, and methods of inducing an immune response by administering the lipopeptide to a mucosal membrane of a subject.
Claims25
A method of inducing an immune response by the delivering of an effective amount of lipid-tailed protein to a mucosal membrane of a subject.
A composition consisting in at least one lipoprotein inducing a mucosal immune response in vivo in absence of toxic adjuvant.
A lipopeptide, wherein the lipopeptide is tailed with a lipid component.
A vaccine composition for mucosal administration containing at least one lipopeptide inducing an B and/or T cell response in vivo in absence of adjuvant.
A method of stimulating T-Lymphocyte responses in vitro after immunization via mucosal administration comprising the following steps:
- a) immunizing BALB/C mice by mucosal administration with a peptide tetanic toxin-pol HIV palmitic antigen,
- b) collecting of ganglia sub-mandibulaires at day 15, and
- c) visualizing T cell responses by labeling target cells with CFSE.
A composition comprising lipid-tailed polypeptide or peptide, said lipid-tailed peptide having at least a lipid residue bound to an epitope T amino acid sequence and optionally at least one epitope B amino acid sequence.
Dependencies are inferred from the claim text.