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OwnerPia M. Challita-Eid, Rene S. Hubert +6inventors
InventorsPia M. Challita-Eid, Rene S. Hubert, Arthur B. Raitano, Daniel E. H. Afar, Elana Levin, Mary Faris, Wangmao Ge, Aya Jakobovits
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A novel gene (designated 158P1H4) and its encoded protein are described. While 158P1H4 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1H4 provides a diagnostic and/or therapeutic target for cancers,. The 158P1H4 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
A method for monitoring 158P1H4 gene products in a biological sample from a patient who has or who is suspected of having cancer, the method comprising:
A composition comprising:
A method of generating a mammalian immune response directed to 158P1H4, the method comprising:
A method of delivering a cytotoxic agent to a cell that expresses 158P1H4, said method comprising:
A method of inducing an immune response to a 158P1H4 protein, said method comprising:
An antibody or fragment thereof that specifically binds to a 158P1H4-related protein.
An assay for detecting the presence of a 158P1H4-related protein or polynucleotide in a biological sample from a patient who has or who is suspected of having cancer, comprising steps of:
An assay for detecting the presence of 158P1H4 mRNA in a biological sample from a patient who has or who is suspected of having cancer, said method comprising:
A composition comprising a polynucleotide from position number 4 through number 1386 of SEQ ID NO.:
A composition comprising SEQ ID NO.:
A composition comprising a polynucleotide that encodes an 158P1H4-related protein that is at least 90% homologous to the entire amino acid sequence shown in SEQ ID NO.:
An analog peptide of eight, nine ten or eleven contiguous amino acids of SEQ ID NO.:
A composition comprising a polynucleotide that encodes at least one peptide set forth in Tables V-XVIII.
A composition comprising a polynucleotide that encodes a peptide region of at least 5 amino acids of SEQ ID NO.:
A composition comprising a polynucleotide that encodes a 158P1H4-re late d protein whose sequence is encoded by the cDNAs contained in the plasmid designated p158P1H4-EBB10 deposited with American Type Culture Collection as Accession No. PTA-3136.
A composition comprising a polypeptide at least 90% homologous to SEQ ID NO.:
A composition comprising a CTL polypeptide epitope from SEQ ID NO.:
A composition comprising a peptide region of at least 5 amino acids of SEQ ID NO.:
A composition comprising a 158P1H4-related protein whose sequence is encoded by the cDNAs contained in the plasmid designated p158P1H4-EBB10 deposited with American Type Culture Collection as Accession No. PTA-3136.
Dependencies are inferred from the claim text.