Inhibition of thrombosis by treatment with P-selectin antagonists
OwnerMichael J. Eppihimer, Robert G. Schaub +1inventors
InventorsMichael J. Eppihimer, Robert G. Schaub, Alan S. Harris
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Abstract
The present invention relates to methods and compositions for the modulation thrombosis, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating leukocyte recruitment, cellular migration, leukocyte rolling velocity, intercellular adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand or fragments thereof, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of modulating thrombosis.
Claims27
A method for treating or inhibiting thrombosis in a subject comprising administering a composition comprising an effective amount of a P-selectin antagonist.
A method for inhibiting cell adhesion to blood vessels in a subject comprising administering a composition comprising an effective amount of soluble PSGL-1, or a fragment thereof having P-selectin ligand activity.
A method for increasing the movement of cells relative to blood vessels in a subject comprising administering a composition comprising an effective amount of soluble PSGL-1, or a fragment thereof having P-selectin ligand activity.
A method for inhibiting the effect of a thrombus-inducing agent in a subject comprising administering a composition comprising an effective amount of an effective amount of soluble PSGL-1, or a fragment thereof having P-selectin ligand activity.
Dependencies are inferred from the claim text.