Methods of treating, preventing, or inhibiting inflammation with exumolide compounds

A method of treating, preventing, or inhibiting inflammation or an inflammatory disease or disorder in a subject comprising administering to the subject at least one Exumolide compound having the following structural formula

• 11
• wherein R1 is H, alkyl, aryl, or alkoxyl;
• R2 and R3 are each independently H, alkyl, or alkoxyl;
• and R4 and R5 are each independently H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or alkoxyl.

A kit comprising at least one Exumolide compound having the following structural formula

• 12
• wherein R1 is H, alkyl, aryl, or alkoxyl;
• R2 and R3 are each independently H, alkyl, or alkoxyl;
• and R4 and R5 are each independently H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or alkoxyl and directions for use.