Cardioprotective composition comprising ceruloplasmin and uses thereof
AssigneeGestilab Inc.
InventorsMircea Alexandru Mateescu, Joanne Paquin, Denis Langlois, Mhamed Aouffen
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Abstract
A cardioprotective composition for protecting heart against oxidative stress and methods for using and preparing the same. More particularly, the cardioprotective composition of the invention comprises a mixture of pyruvate, antioxidant, fatty acids and ceruloplasmin. The cardioprotective composition could be used for the treatment of heart attack/failure, the treatment of ischemic cardiopathy, the conservation of heart before and during transplantation, and the treatment heart oxidative stress related conditions.
Claims22
A cardioprotective composition characterized in that it comprises a therapeutically effective amount of a mixture of pyruvate, at least one antioxidant, at least one lipid and ceruloplasmin and/or a functional derivative thereof.
A method for treating a heart oxidative stress related condition comprising the administration to a patient in need thereof of a therapeutically effective amount of an antioxidative composition comprising pyruvate, at least one antioxidant, at least one lipid and ceruloplasmin and/or a functional derivative thereof.
A method for treating a heart oxidative stress related condition comprising:
- administrating to a patient in need thereof of a therapeutically effective amount of an antioxidative composition comprising:
- pyruvate, at least one antioxidant and ceruloplasmin and/or a functional derivative thereof;
- and
- providing into blood circulation of said patient at least one lipid having a synergistic therapeutic effect on cardiac cells in combination with said antioxidative composition.
A method for the treatment of cardiac cells, comprising contacting said cells with a therapeutically effective amount of an antioxidative composition comprising pyruvate, at least one antioxidant, at least one lipid and ceruloplasmin and/or a functional derivative thereof.
A method for preparing a cardioprotective composition, comprising the steps of:
- a) providing a therapeutically effective amount of i) pyruvate, ii) at least one antioxidant, iii) at least one lipid, and iv) ceruloplasmin and/or a functional derivative thereof;
- and
- b) mixing together the components i), ii), iii) and iv) of step a) in a physiological buffered saline solution to obtain a homologous pharmaceutically acceptable suspension.
Dependencies are inferred from the claim text.