Compositions for sustained action product delivery and methods of use thereof
AssigneeAdvanced Inhalation Research, Inc.
InventorsDavid A. Edwards, Richard P. Batycky, Jennifer L. Schmitke, Nicolas Tsapis, David A. Weitz, Jeffrey S. Hrkach
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Abstract
The present invention features pharmaceutical compositions comprising nanoparticles containing a sustained release bioactive agent, method of making such compositions, and method of therapy using such compositions.
Claims125
A pharmaceutical composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less.
A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 4 microns and about 8 microns and an aerodynamic diameter of between about 1 micron and about 3 microns, said particles comprising between about 5% and about 80% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 5 microns and about 8 microns and an aerodynamic diameter of between about 2.5 and about 3.5, said particles comprising between about 5% and about 70% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 8 microns and about 12.5 microns and an aerodynamic diameter of between about 2 microns and about 3 microns, said particles comprising between about 5 and about 85% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 7.5 microns and about 15 microns and an aerodynamic diameter of between about 4.5 and about 7.5, said particles comprising between 5 and 90% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are colloidal silica.
A pharmaceutical composition comprising phospholipid-containing biodegradable particles and nanoparticles, wherein said nanoparticles comprise Rifampicin and one or more phospholipids.
A method of treating a condition in a patient, comprising the step of administering to said patient a pharmaceutical composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less.
A method of making spray dried particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less, said method comprising the steps of spray drying a solution comprising said nanoparticles or reagents capable of forming nanoparticles under conditions that form spray dried particles.
A composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a nutraceutical agent and having a geometric diameter of about 1 micron or less.
A method of treating a nutritional deficiency in a patient comprising the step of administering to said patient a composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a nutraceutical agent and having a geometric diameter of about 1 micron or less.
Dependencies are inferred from the claim text.