Water soluble paclitaxel derivatives
AssigneePG-TXL Company, L.P.
InventorsChun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Abstract
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
Claims14
A method of enhancing the response of a tumor to irradiation, comprising:
- a) administering to a patient in need of such therapy a radiosensitizing amount of a pharmaceutical composition comprising paclitaxel, docetaxel, eptopside, teniposide, camptothecin or epothilone conjugated to a water soluble polyamino acid polymer and a pharmaceutically acceptable carrier;
- b) irradiating said tumor;
- wherein said conjugated paclitaxel or docetaxel have increased water solubility, efficacy and accumulation within a tumor compared with the corresponding unconjugated drugs.
The method of claim 9, wherein said composition is administered prior to irradiation.
A method of treating cancer comprising:
- a) administering to a patient in need of such therapy a radiosensitizing amount of a pharmaceutical composition comprising paclitaxel, docetaxel, eptopside, teniposide, camptothecin or epothilone conjugated to a polyglutamic acid polymer and a pharmaceutically acceptable carrier;
- and
- b) irradiating said tumor.
Dependencies are inferred from the claim text.